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St6galnac2 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303692, updated on 13-Apr-2024

Summary

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Symbol
St6galnac2provided by RGD
Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2provided by RGD
Primary source
RGD:1560747
See related
Ensembl:ENSRNOG00000012083 AllianceGenome:RGD:1560747
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat7b
Summary
Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in protein O-linked glycosylation and protein sialylation. Predicted to be located in Golgi apparatus. Predicted to be integral component of membrane. Orthologous to human ST6GALNAC2 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 139.8), Heart (RPKM 126.6) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St6galnac2 in Genome Data Viewer
Location:
10q32.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102409048..102427299, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101910220..101928412, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105650866..105668579, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA R38 Neighboring gene uncharacterized LOC108352161 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Neighboring gene matrix remodeling associated 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression system for structural and functional studies of human glycosylation enzymes. Moremen KW, et al. Nat Chem Biol, 2018 Feb. PMID 29251719, Free PMC Article
  2. Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells. Samyn-Petit B, et al. Biochim Biophys Acta, 2000 Apr 6. PMID 10742600
  3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC124782

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Names
Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
ST6 GalNAc alpha-2,6-sialyltransferase 2
ST6GALNAC2, alpha-2,6-sialyltransferase 2
ST6GalNAc II
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase II ()
sialyltransferase 7B
NP_001026822.1
XP_038942127.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031652.2 → NP_001026822.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2

    See identical proteins and their annotated locations for NP_001026822.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I6A9Z9, A6HKY6, F7FDY5, Q6ZYN8
    Related
    ENSRNOP00000016622.4, ENSRNOT00000016622.7
    Conserved Domains (1) summary
    pfam00777
    Location:110 → 372
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    102409048..102427299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086199.2 → XP_038942127.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:88 → 291
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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