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Engase endo-beta-N-acetylglucosaminidase [ Rattus norvegicus (Norway rat) ]

Gene ID: 303702, updated on 10-Oct-2024

Summary

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Official Symbol
Engaseprovided by RGD
Official Full Name
endo-beta-N-acetylglucosaminidaseprovided by RGD
Primary source
RGD:1310868
See related
EnsemblRapid:ENSRNOG00000027498 AllianceGenome:RGD:1310868
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310868
Summary
Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be involved in protein deglycosylation. Predicted to be located in cytosol. Orthologous to human ENGASE (endo-beta-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 75.1), Thymus (RPKM 58.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Engase in Genome Data Viewer
Location:
10q32.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (104205753..104218416)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103707169..103719833)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (107502636..107515300)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548791 Neighboring gene C1q and TNF related 1 Neighboring gene RNA binding fox-1 homolog 3 Neighboring gene uncharacterized LOC134480911 Neighboring gene signal recognition particle 19 kDa protein-like Neighboring gene uncharacterized LOC134480909

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells. Huang C, et al. Proc Natl Acad Sci U S A, 2015 Feb 3. PMID 25605922, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein deglycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytosolic endo-beta-N-acetylglucosaminidase
NP_001100540.1
XP_006247865.1
XP_006247866.1
XP_038942141.1
XP_063125315.1
XP_063125316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107070.1 → NP_001100540.1  cytosolic endo-beta-N-acetylglucosaminidase

    See identical proteins and their annotated locations for NP_001100540.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A0A8I6GLC2, A6HL61
    Conserved Domains (1) summary
    cd06547
    Location:116 → 426
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    104205753..104218416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247803.3 → XP_006247865.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLC2, D4AE03
    Conserved Domains (1) summary
    cd06547
    Location:116 → 426
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

  2. XM_063269246.1 → XP_063125316.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X5

  3. XM_039086213.2 → XP_038942141.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X3

    UniProtKB/TrEMBL
    A0A8I6GLC2
    Conserved Domains (1) summary
    cd06547
    Location:27 → 337
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

  4. XM_063269245.1 → XP_063125315.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X4

  5. XM_006247804.5 → XP_006247866.1  cytosolic endo-beta-N-acetylglucosaminidase isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLC2
    Related
    ENSRNOP00000038006.6, ENSRNOT00000038088.7
    Conserved Domains (1) summary
    cd06547
    Location:93 → 403
    GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

RNA

  1. XR_005489867.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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