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Slc16a6 solute carrier family 16, member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303772, updated on 2-Nov-2024

Summary

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Official Symbol
Slc16a6provided by RGD
Official Full Name
solute carrier family 16, member 6provided by RGD
Primary source
RGD:735117
See related
EnsemblRapid:ENSRNOG00000000245 AllianceGenome:RGD:735117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MCT 6; MCT 7; Mct7B
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in carboxylic acid transmembrane transport. Located in basolateral plasma membrane. Orthologous to human SLC16A6 (solute carrier family 16 member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 79.5), Testes (RPKM 61.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc16a6 in Genome Data Viewer
Location:
10q32.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (94923888..94946990, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (94424377..94447482, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (97733701..97758723, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 13 Neighboring gene archaelysin family metallopeptidase 2 Neighboring gene 5E5 antigen-like Neighboring gene arylsulfatase G Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene uncharacterized LOC100912202 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian monocarboxylate transporter 7 (MCT7/Slc16a6) is a novel facilitative taurine transporter. Higuchi K, et al. J Biol Chem, 2022 Apr. PMID 35257743, Free PMC Article
  2. Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Price NT, et al. Biochem J, 1998 Jan 15. PMID 9425115, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94224

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in taurine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
monocarboxylate transporter 7
Names
monocarboxylate transporter 6
monocarboxylate transporter 7B
solute carrier family 16 (monocarboxylic acid transporters), member 6
solute carrier family 16, member 6 (monocarboxylic acid transporter 7)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415132.2 → NP_001402061.1  monocarboxylate transporter 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q7TMR7
    UniProtKB/TrEMBL
    A0A0G2JVH2

  2. NM_001415133.2 → NP_001402062.1  monocarboxylate transporter 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    F7EP61
    Related
    ENSRNOP00000069483.2, ENSRNOT00000078059.3

  3. NM_198760.3 → NP_942055.1  monocarboxylate transporter 7 isoform 1

    See identical proteins and their annotated locations for NP_942055.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q7TMR7
    UniProtKB/TrEMBL
    A0A0G2JVH2, A6HKB2
    Conserved Domains (1) summary
    cd17422
    Location:24 → 471
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    94923888..94946990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247619.5 → XP_006247681.1  monocarboxylate transporter 7 isoform X2

    See identical proteins and their annotated locations for XP_006247681.1

    UniProtKB/Swiss-Prot
    Q7TMR7
    UniProtKB/TrEMBL
    A0A0G2JVH2, A6HKB2
    Conserved Domains (1) summary
    cd17422
    Location:24 → 471
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  2. XM_017597350.3 → XP_017452839.1  monocarboxylate transporter 7 isoform X1

    UniProtKB/TrEMBL
    A6HKB2
    Conserved Domains (1) summary
    cd17422
    Location:29 → 476
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  3. XM_039086229.2 → XP_038942157.1  monocarboxylate transporter 7 isoform X2

    UniProtKB/Swiss-Prot
    Q7TMR7
    UniProtKB/TrEMBL
    A0A0G2JVH2, A6HKB2
    Conserved Domains (1) summary
    cd17422
    Location:24 → 471
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters

  4. XM_039086231.2 → XP_038942159.1  monocarboxylate transporter 7 isoform X2

    UniProtKB/Swiss-Prot
    Q7TMR7
    UniProtKB/TrEMBL
    A0A0G2JVH2, A6HKB2
    Conserved Domains (1) summary
    cd17422
    Location:24 → 471
    MFS_MCT7; Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TMR7.1 GenPept UniProtKB/Swiss-Prot:Q7TMR7

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