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Aifm3 apoptosis inducing factor, mitochondria associated 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303786, updated on 18-Sep-2024

Summary

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Official Symbol
Aifm3provided by RGD
Official Full Name
apoptosis inducing factor, mitochondria associated 3provided by RGD
Primary source
RGD:1306028
See related
EnsemblRapid:ENSRNOG00000037957 AllianceGenome:RGD:1306028
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306028
Summary
Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human AIFM3 (apoptosis inducing factor mitochondria associated 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 77.5), Kidney (RPKM 13.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Aifm3 in Genome Data Viewer
Location:
11q23
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (97009100..97030601, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (83504859..83523630, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (87364452..87380705)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene THAP domain containing 7 Neighboring gene leucine zipper like post translational regulator 1 Neighboring gene CRK like proto-oncogene, adaptor protein Neighboring gene transfer RNA serine (anticodon UGA) 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Apoptosis-inducing factor is involved in gentamicin-induced vestibular hair cell death. Zhang D, et al. ORL J Otorhinolaryngol Relat Spec, 2012. PMID 22085972
  2. Role for apoptosis-inducing factor in the physiological death of cerebellar neurons. Blancas S, et al. Neurochem Int, 2011 Jul. PMID 21447364
  3. Molecular cloning and characterization of a human AIF-like gene with ability to induce apoptosis. Xie Q, et al. J Biol Chem, 2005 May 20. PMID 15764604
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AIF participates in GM-induced apoptosis of vestibular hair cells.
    Title: Apoptosis-inducing factor is involved in gentamicin-induced vestibular hair cell death.
  2. Apoptosis-inducing factor is involved in apoptotic-like death of cerebellar granule neurons and could be an alternative mechanism of neuronal death during cerebellar development.
    Title: Role for apoptosis-inducing factor in the physiological death of cerebellar neurons.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC109275

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apoptosis-inducing factor 3
Names
apoptosis-inducing factor, mitochondrion-associated 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013977.3 → NP_001013999.2  apoptosis-inducing factor 3

    Status: VALIDATED

    Source sequence(s)
    CB769270, JAXUCZ010000011
    UniProtKB/TrEMBL
    D3ZF03
    Related
    ENSRNOP00000048427.2, ENSRNOT00000040978.6
    Conserved Domains (5) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam00070
    Location:333 → 413
    Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
    pfam07992
    Location:194 → 492
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:511 → 561
    Reductase_C; Reductase C-terminal
    cl21454
    Location:195 → 284
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    97009100..97030601 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270455.1 → XP_063126525.1  apoptosis-inducing factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A793
    Related
    ENSRNOP00000088997.1, ENSRNOT00000112032.2

  2. XM_039088260.2 → XP_038944188.1  apoptosis-inducing factor 3 isoform X1

    Conserved Domains (3) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:194 → 492
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:511 → 561
    Reductase_C; Reductase C-terminal

  3. XM_063270454.1 → XP_063126524.1  apoptosis-inducing factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A793

  4. XM_039088259.2 → XP_038944187.1  apoptosis-inducing factor 3 isoform X1

    Conserved Domains (3) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:194 → 492
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:511 → 561
    Reductase_C; Reductase C-terminal

  5. XM_008768875.4 → XP_008767097.1  apoptosis-inducing factor 3 isoform X1

    Conserved Domains (3) summary
    cd03478
    Location:70 → 163
    Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
    pfam07992
    Location:194 → 492
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14759
    Location:511 → 561
    Reductase_C; Reductase C-terminal

  6. XM_063270456.1 → XP_063126526.1  apoptosis-inducing factor 3 isoform X3

RNA

  1. XR_010055949.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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