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Osbpl11 oxysterol binding protein-like 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303888, updated on 2-Nov-2024

Summary

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Official Symbol
Osbpl11provided by RGD
Official Full Name
oxysterol binding protein-like 11provided by RGD
Primary source
RGD:1307294
See related
EnsemblRapid:ENSRNOG00000001782 AllianceGenome:RGD:1307294
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable sterol binding activity. Predicted to be involved in fat cell differentiation and positive regulation of sequestering of triglyceride. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus; cytosol; and membrane. Orthologous to human OSBPL11 (oxysterol binding protein like 11). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 187.6), Thymus (RPKM 153.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Osbpl11 in Genome Data Viewer
Location:
11q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (81038759..81121887, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67533669..67616795, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (70770509..70855425, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 4 Neighboring gene uncharacterized LOC120095666 Neighboring gene uncharacterized LOC134481083 Neighboring gene leishmanolysin like peptidase Neighboring gene ribosomal protein L35A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype. Zhou Y, et al. PLoS One, 2012. PMID 23028956, Free PMC Article
  2. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107090.2 → NP_001100560.1  oxysterol-binding protein-related protein 11

    See identical proteins and their annotated locations for NP_001100560.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168952
    UniProtKB/TrEMBL
    A6IRL8, B5DF74, F7FPV5
    Related
    ENSRNOP00000002428.5, ENSRNOT00000002428.8
    Conserved Domains (3) summary
    cd13291
    Location:72 → 178
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:74 → 164
    PH; PH domain
    pfam01237
    Location:380 → 740
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    81038759..81121887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248451.5 → XP_006248513.1  oxysterol-binding protein-related protein 11 isoform X3

    See identical proteins and their annotated locations for XP_006248513.1

    Conserved Domains (3) summary
    cd13291
    Location:4 → 110
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:6 → 96
    PH; PH domain
    pfam01237
    Location:312 → 672
    Oxysterol_BP; Oxysterol-binding protein

  2. XM_006248450.5 → XP_006248512.1  oxysterol-binding protein-related protein 11 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A240
    Related
    ENSRNOP00000085645.1, ENSRNOT00000104334.2
    Conserved Domains (3) summary
    cd13291
    Location:72 → 174
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:74 → 164
    PH; PH domain
    pfam01237
    Location:321 → 681
    Oxysterol_BP; Oxysterol-binding protein

  3. XM_063270516.1 → XP_063126586.1  oxysterol-binding protein-related protein 11 isoform X3

  4. XM_006248452.4 → XP_006248514.1  oxysterol-binding protein-related protein 11 isoform X3

    See identical proteins and their annotated locations for XP_006248514.1

    Conserved Domains (3) summary
    cd13291
    Location:4 → 110
    PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain
    pfam00169
    Location:6 → 96
    PH; PH domain
    pfam01237
    Location:312 → 672
    Oxysterol_BP; Oxysterol-binding protein

  5. XM_063270515.1 → XP_063126585.1  oxysterol-binding protein-related protein 11 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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