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Bbx BBX high mobility group box domain containing [ Rattus norvegicus (Norway rat) ]

Gene ID: 303970, updated on 10-Jul-2024

Summary

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Symbol
Bbxprovided by RGD
Full Name
BBX high mobility group box domain containingprovided by RGD
Primary source
RGD:1309769
See related
EnsemblRapid:ENSRNOG00000001971 AllianceGenome:RGD:1309769
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone development. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human BBX (BBX high mobility group box domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 228.3), Adrenal (RPKM 142.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Bbx in Genome Data Viewer
Location:
11q21
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (63850034..64097700)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (50381249..50628934)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (52983286..53228557)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480992 Neighboring gene ribosomal protein L26, pseudogene 9 Neighboring gene uncharacterized LOC134480993 Neighboring gene uncharacterized LOC134480994

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility. Wang CY, et al. Biol Reprod, 2016 Sep. PMID 27465138, Free PMC Article
  2. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. Bassett JH, et al. PLoS Genet, 2012. PMID 22876197, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that loss of BBX induces apoptosis of postmeiotic spermatids and results in spermiogenesis defects and infertility.
    Title: PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
HMG box transcription factor BBX
Names
BBX, HMG-box containing
HMG box transcription factor BBX-like
bobby sox homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079938.1 → NP_001073407.1  HMG box transcription factor BBX

    See identical proteins and their annotated locations for NP_001073407.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129113
    UniProtKB/TrEMBL
    A1L1L0, A6IQT5
    Related
    ENSRNOP00000002700.5, ENSRNOT00000002700.8
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam09667
    Location:191 → 302
    DUF2028; Domain of unknown function (DUF2028)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    63850034..64097700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088363.2 → XP_038944291.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  2. XM_063270545.1 → XP_063126615.1  HMG box transcription factor BBX isoform X3

    UniProtKB/TrEMBL
    A1L1L0, A6IQT5

  3. XM_063270541.1 → XP_063126611.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4

  4. XM_063270544.1 → XP_063126614.1  HMG box transcription factor BBX isoform X3

    UniProtKB/TrEMBL
    A1L1L0, A6IQT5

  5. XM_063270557.1 → XP_063126627.1  HMG box transcription factor BBX isoform X6

    UniProtKB/TrEMBL
    A6IQT5

  6. XM_063270552.1 → XP_063126622.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6

  7. XM_063270558.1 → XP_063126628.1  HMG box transcription factor BBX isoform X7

    UniProtKB/TrEMBL
    A6IQT5
    Related
    ENSRNOP00000089981.2, ENSRNOT00000119802.2

  8. XM_008768637.4 → XP_008766859.1  HMG box transcription factor BBX isoform X1

    See identical proteins and their annotated locations for XP_008766859.1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  9. XM_039088366.2 → XP_038944294.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6
    Conserved Domains (2) summary
    cd01388
    Location:54 → 112
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:153 → 285
    DUF2028; Domain of unknown function (DUF2028)

  10. XM_017598008.3 → XP_017453497.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  11. XM_008768634.4 → XP_008766856.1  HMG box transcription factor BBX isoform X1

    See identical proteins and their annotated locations for XP_008766856.1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  12. XM_039088365.2 → XP_038944293.1  HMG box transcription factor BBX isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZRG6
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  13. XM_008768638.4 → XP_008766860.1  HMG box transcription factor BBX isoform X3

    See identical proteins and their annotated locations for XP_008766860.1

    UniProtKB/TrEMBL
    A1L1L0, A6IQT5
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam09667
    Location:191 → 302
    DUF2028; Domain of unknown function (DUF2028)

  14. XM_008768641.4 → XP_008766863.1  HMG box transcription factor BBX isoform X5

    UniProtKB/TrEMBL
    A0A0G2JXW5, A6IQT5
    Related
    ENSRNOP00000070428.2, ENSRNOT00000083438.3
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
    pfam09667
    Location:191 → 302
    DUF2028; Domain of unknown function (DUF2028)

  15. XM_008768640.4 → XP_008766862.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6
    Conserved Domains (2) summary
    cd01388
    Location:54 → 112
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:153 → 285
    DUF2028; Domain of unknown function (DUF2028)

  16. XM_063270535.1 → XP_063126605.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4

  17. XM_063270536.1 → XP_063126606.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4

  18. XM_063270553.1 → XP_063126623.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6

  19. XM_063270537.1 → XP_063126607.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4

  20. XM_017598001.3 → XP_017453490.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  21. XM_063270549.1 → XP_063126619.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6

  22. XM_063270539.1 → XP_063126609.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4

  23. XM_017598004.3 → XP_017453493.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  24. XM_063270550.1 → XP_063126620.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6

  25. XM_017598002.3 → XP_017453491.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  26. XM_063270543.1 → XP_063126613.1  HMG box transcription factor BBX isoform X3

    UniProtKB/TrEMBL
    A1L1L0, A6IQT5

  27. XM_063270551.1 → XP_063126621.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6

  28. XM_063270538.1 → XP_063126608.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4

  29. XM_063270556.1 → XP_063126626.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6

  30. XM_063270534.1 → XP_063126604.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4

  31. XM_017598003.3 → XP_017453492.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  32. XM_017598005.3 → XP_017453494.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  33. XM_063270554.1 → XP_063126624.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6

  34. XM_017598007.3 → XP_017453496.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  35. XM_017598009.3 → XP_017453498.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  36. XM_063270548.1 → XP_063126618.1  HMG box transcription factor BBX isoform X3

    UniProtKB/TrEMBL
    A1L1L0, A6IQT5

  37. XM_039088364.2 → XP_038944292.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4
    Conserved Domains (2) summary
    cd01388
    Location:79 → 150
    SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...
    pfam09667
    Location:191 → 323
    DUF2028; Domain of unknown function (DUF2028)

  38. XM_063270542.1 → XP_063126612.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4

  39. XM_063270540.1 → XP_063126610.1  HMG box transcription factor BBX isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZRG6, A0A8I6ADK4

  40. XM_063270547.1 → XP_063126617.1  HMG box transcription factor BBX isoform X3

    UniProtKB/TrEMBL
    A1L1L0, A6IQT5

  41. XM_063270546.1 → XP_063126616.1  HMG box transcription factor BBX isoform X3

    UniProtKB/TrEMBL
    A1L1L0, A6IQT5

  42. XM_063270555.1 → XP_063126625.1  HMG box transcription factor BBX isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZRG6
Nucleotide Protein Strain
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