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Tomm70 translocase of outer mitochondrial membrane 70 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304017, updated on 11-Apr-2024

Summary

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Official Symbol
Tomm70provided by RGD
Official Full Name
translocase of outer mitochondrial membrane 70provided by RGD
Primary source
RGD:1303049
See related
Ensembl:ENSRNOG00000001640 AllianceGenome:RGD:1303049
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
TOM70; Tomm70a
Summary
Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; protein targeting to mitochondrion; and response to thyroxine. Is integral component of mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Used to study congestive heart failure. Biomarker of hypothyroidism. Orthologous to human TOMM70 (translocase of outer mitochondrial membrane 70). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 219.0), Liver (RPKM 153.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tomm70 in Genome Data Viewer
Location:
11q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (56847837..56886302, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (43378719..43417166, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (45477053..45511409, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ribosome biogenesis protein NSA2 homolog pseudogene Neighboring gene nitrilase family, member 2 Neighboring gene uncharacterized LOC108352328 Neighboring gene transmembrane protein 45A2 Neighboring gene uncharacterized LOC134481039

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphoproteome mapping of cardiomyocyte mitochondria in a rat model of heart failure. Giorgianni F, et al. Mol Cell Biochem, 2014 Apr. PMID 24395194, Free PMC Article
  2. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. Alvarez-Dolado M, et al. J Neurochem, 1999 Dec. PMID 10582581
  3. Regulation of protein kinase C-epsilon and its age-dependence. Kang C, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27919679
  4. Characterization of rat TOM70 as a receptor of the preprotein translocase of the mitochondrial outer membrane. Suzuki H, et al. J Cell Sci, 2002 May 1. PMID 11956321
  5. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Santos JM, et al. Diabetes Metab Res Rev, 2013 Mar. PMID 23255365, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112570

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables mitochondrion targeting sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cell growth involved in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of defense response to virus by host ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of interferon-beta production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to thyroxine IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import receptor subunit TOM70
Names
mitochondrial precursor proteins import receptor
translocase of outer membrane 70 kDa subunit
translocase of outer mitochondrial membrane protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212519.2 → NP_997684.1  mitochondrial import receptor subunit TOM70

    See identical proteins and their annotated locations for NP_997684.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098640
    UniProtKB/Swiss-Prot
    Q75Q39
    UniProtKB/TrEMBL
    A6IQN3
    Related
    ENSRNOP00000002238.6, ENSRNOT00000002238.7
    Conserved Domains (2) summary
    TIGR00990
    Location:116 → 603
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:116 → 144
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    56847837..56886302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768645.4 → XP_008766867.1  mitochondrial import receptor subunit TOM70 isoform X1

    Conserved Domains (3) summary
    sd00006
    Location:116 → 144
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:116 → 148
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:115 → 186
    TPR_11; TPR repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q75Q39.1 GenPept UniProtKB/Swiss-Prot:Q75Q39

Gene LinkOut

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