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Arl13b ADP-ribosylation factor like GTPase 13B [ Rattus norvegicus (Norway rat) ]

Gene ID: 304037, updated on 2-Nov-2024

Summary

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Official Symbol
Arl13bprovided by RGD
Official Full Name
ADP-ribosylation factor like GTPase 13Bprovided by RGD
Primary source
RGD:1584979
See related
EnsemblRapid:ENSRNOG00000047194 AllianceGenome:RGD:1584979
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including nervous system development; non-motile cilium assembly; and receptor localization to non-motile cilium. Predicted to act upstream of or within dorsal/ventral pattern formation; heart looping; and left/right axis specification. Predicted to be located in axoneme. Predicted to be active in ciliary membrane; motile cilium; and non-motile cilium. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Orthologous to human ARL13B (ADP ribosylation factor like GTPase 13B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 69.2), Kidney (RPKM 51.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arl13b in Genome Data Viewer
Location:
11p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (13597538..13663681, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (150100..217103, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (1122567..1188209, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene 5.8S ribosomal RNA Neighboring gene solute carrier family 22 (organic anion transporter), member 7, pseudogene 1 Neighboring gene syntaxin 19 Neighboring gene protein S

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats. Jiang L, et al. Biochem Pharmacol, 2024 Sep. PMID 39038552
  2. Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. Thompson CL, et al. FASEB J, 2016 Feb. PMID 26499268
  3. Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts. Li Y, et al. J Am Soc Nephrol, 2016 Dec. PMID 27153923, Free PMC Article
  4. Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Cantagrel V, et al. Am J Hum Genet, 2008 Aug. PMID 18674751, Free PMC Article
  5. A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice. Heydet D, et al. Dev Neurobiol, 2013 Jan. PMID 22581473

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats.
    Title: ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia/reperfusion in rats.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation ISO
Inferred from Sequence Orthology
more info
  
involved_in formation of radial glial scaffolds ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart looping ISO
Inferred from Sequence Orthology
more info
  
involved_in interneuron migration from the subpallium to the cortex ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within left/right axis specification ISO
Inferred from Sequence Orthology
more info
  
involved_in neural tube patterning ISO
Inferred from Sequence Orthology
more info
  
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor localization to non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-like protein 13B
Names
ADP-ribosylation factor-like 13B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107101.1 → NP_001100571.1  ADP-ribosylation factor-like protein 13B

    See identical proteins and their annotated locations for NP_001100571.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474112
    UniProtKB/TrEMBL
    A6KSZ8, M0RDU9
    Related
    ENSRNOP00000067810.2, ENSRNOT00000074108.5
    Conserved Domains (2) summary
    cd04161
    Location:23 → 189
    Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
    pfam00071
    Location:24 → 172
    Ras; Ras family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    13597538..13663681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240716.5 → XP_006240778.1  ADP-ribosylation factor-like protein 13B isoform X2

    Conserved Domains (2) summary
    cd04161
    Location:1 → 164
    Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
    cl23809
    Location:390 → 450
    DUF4271; Domain of unknown function (DUF4271)

  2. XM_039088392.2 → XP_038944320.1  ADP-ribosylation factor-like protein 13B isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZXD0
    Related
    ENSRNOP00000084231.1, ENSRNOT00000099706.2
    Conserved Domains (1) summary
    cd04161
    Location:23 → 189
    Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13

  3. XM_039088391.2 → XP_038944319.1  ADP-ribosylation factor-like protein 13B isoform X1

    Conserved Domains (1) summary
    cd04161
    Location:23 → 189
    Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
Nucleotide Protein Strain
Heading Accession and Version

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