U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Morc3 MORC family CW-type zinc finger 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304074, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
Morc3provided by RGD
Official Full Name
MORC family CW-type zinc finger 3provided by RGD
Primary source
RGD:1307924
See related
EnsemblRapid:ENSRNOG00000026236 AllianceGenome:RGD:1307924
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zcwcc3
Summary
Predicted to enable methylated histone binding activity. Predicted to act upstream of or within several processes, including maintenance of protein location in nucleus; negative regulation of fibroblast proliferation; and protein stabilization. Predicted to be located in PML body. Orthologous to human MORC3 (MORC family CW-type zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 269.2), Spleen (RPKM 247.5) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Morc3 in Genome Data Viewer
Location:
11q11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (46621575..46664315)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (33151906..33194650)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (34051928..34094697)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene DOP1 leucine zipper like protein B Neighboring gene interferon induced transmembrane protein3, pseudogene 2 Neighboring gene chromatin assembly factor 1 subunit B Neighboring gene claudin 14

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Takahashi K, et al. Mol Biol Cell, 2007 May. PMID 17332504, Free PMC Article
  2. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within maintenance of protein location in nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
MORC family CW-type zinc finger protein 3
Names
microrchidia 3
zinc finger, CW-type with coiled-coil domain 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395628.1 → NP_001382557.1  MORC family CW-type zinc finger protein 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    A0A096MIX0
    Conserved Domains (4) summary
    TIGR00606
    Location:697 → 872
    rad50
    cd16931
    Location:18 → 135
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:409 → 446
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:249 → 382
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    46621575..46664315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270588.1 → XP_063126658.1  MORC family CW-type zinc finger protein 3 isoform X5

  2. XM_063270584.1 → XP_063126654.1  MORC family CW-type zinc finger protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A096MIX0
    Related
    ENSRNOP00000067908.3, ENSRNOT00000076473.4

  3. XM_063270586.1 → XP_063126656.1  MORC family CW-type zinc finger protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A096MIX0

  4. XM_063270585.1 → XP_063126655.1  MORC family CW-type zinc finger protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A096MIX0

  5. XM_039088413.2 → XP_038944341.1  MORC family CW-type zinc finger protein 3 isoform X3

    UniProtKB/TrEMBL
    A6KPZ0
    Conserved Domains (3) summary
    TIGR00606
    Location:509 → 684
    rad50
    pfam07496
    Location:221 → 258
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:61 → 194
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

  6. XM_039088414.2 → XP_038944342.1  MORC family CW-type zinc finger protein 3 isoform X3

    UniProtKB/TrEMBL
    A6KPZ0
    Conserved Domains (3) summary
    TIGR00606
    Location:509 → 684
    rad50
    pfam07496
    Location:221 → 258
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:61 → 194
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

  7. XM_039088415.2 → XP_038944343.1  MORC family CW-type zinc finger protein 3 isoform X4

    UniProtKB/TrEMBL
    A6KPZ0
    Conserved Domains (3) summary
    TIGR00606
    Location:434 → 609
    rad50
    pfam07496
    Location:146 → 183
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:1 → 119
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107109.1: Suppressed sequence

    Description
    NM_001107109.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools