Cbr3 carbonyl reductase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cbr3provided by RGD
Official Full Name: carbonyl reductase 3provided by RGD
Primary source: RGD:1309728
See related: EnsemblRapid:ENSRNOG00000001701 AllianceGenome:RGD:1309728
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 3-keto sterol reductase activity and carbonyl reductase (NADPH) activity. Involved in phylloquinone catabolic process. Predicted to be located in cytosol and nucleoplasm. Orthologous to human CBR3 (carbonyl reductase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 76.1), Lung (RPKM 47.9) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 11q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (46478295..46486555)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (33008615..33016877)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (33909417..33917674)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH137117 (e-PCR)
- UniSTS:219205

RH127062 (e-PCR)
- UniSTS:209251

RH137712 (e-PCR)
- UniSTS:219799

Cbr3 (e-PCR), detects polymorphism
- UniSTS:259050

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-keto sterol reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH dehydrogenase (quinone) activity	ISO Inferred from Sequence Orthology more info
enables NADPH dehydrogenase (quinone) activity	ISS Inferred from Sequence or Structural Similarity more info
enables carbonyl reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonyl reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables carbonyl reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cognition	ISO Inferred from Sequence Orthology more info
involved_in phylloquinone catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: carbonyl reductase [NADPH] 3

Names: monomeric carbonyl reductase 3; quinone reductase CBR3

NP_001100580.1

EC 1.1.1.184

EC 1.6.5.10

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107110.1 → NP_001100580.1 carbonyl reductase [NADPH] 3

See identical proteins and their annotated locations for NP_001100580.1

Status: PROVISIONAL

Source sequence(s)

CH474083

UniProtKB/Swiss-Prot

B2GV72

Related

ENSRNOP00000002310.4, ENSRNOT00000002310.8

Conserved Domains (2) summary

cd05324
Location:6 → 277

carb_red_PTCR-like_SDR_c; Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs

pfam00106
Location:6 → 241

adh_short; short chain dehydrogenase