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Lrrc8e leucine rich repeat containing 8 VRAC subunit E [ Rattus norvegicus (Norway rat) ]

Gene ID: 304203, updated on 2-Nov-2024

Summary

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Official Symbol
Lrrc8eprovided by RGD
Official Full Name
leucine rich repeat containing 8 VRAC subunit Eprovided by RGD
Primary source
RGD:1311979
See related
EnsemblRapid:ENSRNOG00000028460 AllianceGenome:RGD:1311979
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311979
Summary
Predicted to enable volume-sensitive anion channel activity. Predicted to be involved in several processes, including aspartate transmembrane transport; cell volume homeostasis; and cyclic-GMP-AMP transmembrane import across plasma membrane. Predicted to be located in endoplasmic reticulum membrane and lysosomal membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LRRC8E (leucine rich repeat containing 8 VRAC subunit E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 51.3), Adrenal (RPKM 31.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lrrc8e in Genome Data Viewer
Location:
12p12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (7376103..7387250)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (2578240..2589407)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2557267..2568416, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ecotropic viral integration site 5-like Neighboring gene proline rich 36 Neighboring gene mitogen activated protein kinase kinase 7 Neighboring gene transforming growth factor beta receptor 3 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels. Lutter D, et al. J Cell Sci, 2017 Mar 15. PMID 28193731
  2. LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength. Syeda R, et al. Cell, 2016 Jan 28. PMID 26824658, Free PMC Article
  3. Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Voss FK, et al. Science, 2014 May 9. PMID 24790029
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124693

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables volume-sensitive anion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to volume-sensitive anion channel activity ISO
Inferred from Sequence Orthology
more info
  
enables volume-sensitive anion channel activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to volume-sensitive anion channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aspartate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in aspartate transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell volume homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell volume homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to osmotic stress ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in cyclic-GMP-AMP transmembrane import across plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic anion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in monoatomic anion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of monoatomic ion channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of monoatomic ion channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of monoatomic ion channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
volume-regulated anion channel subunit LRRC8E
Names
leucine rich repeat containing 8 family, member E
leucine-rich repeat-containing protein 8E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034139.2 → NP_001029311.1  volume-regulated anion channel subunit LRRC8E

    See identical proteins and their annotated locations for NP_001029311.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q3KRC6
    Conserved Domains (4) summary
    cd00116
    Location:526 → 790
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:559 → 582
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 330
    Pannexin_like; Pannexin-like TM region of LRRC8
    pfam13855
    Location:676 → 733
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    7376103..7387250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248763.5 → XP_006248825.1  volume-regulated anion channel subunit LRRC8E isoform X1

    See identical proteins and their annotated locations for XP_006248825.1

    UniProtKB/Swiss-Prot
    Q3KRC6
    Conserved Domains (4) summary
    cd00116
    Location:526 → 790
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:559 → 582
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 330
    Pannexin_like; Pannexin-like TM region of LRRC8
    pfam13855
    Location:676 → 733
    LRR_8; Leucine rich repeat

  2. XM_006248764.5 → XP_006248826.1  volume-regulated anion channel subunit LRRC8E isoform X1

    See identical proteins and their annotated locations for XP_006248826.1

    UniProtKB/Swiss-Prot
    Q3KRC6
    Conserved Domains (4) summary
    cd00116
    Location:526 → 790
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:559 → 582
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12534
    Location:1 → 330
    Pannexin_like; Pannexin-like TM region of LRRC8
    pfam13855
    Location:676 → 733
    LRR_8; Leucine rich repeat

  3. XM_063271246.1 → XP_063127316.1  volume-regulated anion channel subunit LRRC8E isoform X1

    UniProtKB/Swiss-Prot
    Q3KRC6
    Related
    ENSRNOP00000037487.3, ENSRNOT00000035142.6

  4. XM_063271247.1 → XP_063127317.1  volume-regulated anion channel subunit LRRC8E isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KRC6.1 GenPept UniProtKB/Swiss-Prot:Q3KRC6

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