Zkscan5 zinc finger with KRAB and SCAN domains 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zkscan5provided by RGD
Official Full Name: zinc finger with KRAB and SCAN domains 5provided by RGD
Primary source: RGD:1311175
See related: EnsemblRapid:ENSRNOG00000059552 AllianceGenome:RGD:1311175
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zfp95
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZKSCAN5 (zinc finger with KRAB and SCAN domains 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 64.7), Heart (RPKM 64.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (14498342..14519537, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (9384561..9405763, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (11154807..11176002, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein with KRAB and SCAN domains 5

Names: zinc finger protein 95

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107119.1 → NP_001100589.1 zinc finger protein with KRAB and SCAN domains 5

See identical proteins and their annotated locations for NP_001100589.1

Status: PROVISIONAL

Source sequence(s)

CH474012

UniProtKB/TrEMBL

A0A0G2K008, A6K1E4

Related

ENSRNOP00000071257.2, ENSRNOT00000090073.3

Conserved Domains (7) summary

smart00431
Location:45 → 153

SCAN; leucine rich region

COG5048
Location:320 → 747

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:543 → 563

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:541 → 563

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:218 → 248

KRAB; KRAB box

pfam02023
Location:45 → 132

SCAN; SCAN domain

pfam13465
Location:381 → 404

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

14498342..14519537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089340.2 → XP_038945268.1 zinc finger protein with KRAB and SCAN domains 5 isoform X1

Conserved Domains (4) summary

cd07765
Location:71 → 101

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

COG5048
Location:384 → 670

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:396 → 416

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:234 → 258

zf-H2C2_2; Zinc-finger double domain