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Papolb poly(A) polymerase beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 304300, updated on 10-Jul-2024

Summary

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Official Symbol
Papolbprovided by RGD
Official Full Name
poly(A) polymerase betaprovided by RGD
Primary source
RGD:1310946
See related
EnsemblRapid:ENSRNOG00000082193 AllianceGenome:RGD:1310946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in endoplasmic reticulum and nucleus. Orthologous to human PAPOLB (poly(A) polymerase beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See Papolb in Genome Data Viewer
Location:
12p11
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (17157757..17160103)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (12044275..12046621)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (14112426..14114772)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain, phosphoinositide interacting 2 Neighboring gene monocyte to macrophage differentiation-associated 2 Neighboring gene Rap associating with DIL domain Neighboring gene adaptor related protein complex 5 subunit zeta 1 Neighboring gene forkhead box K1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An intronless gene encoding a poly(A) polymerase is specifically expressed in testis. Lee YJ, et al. FEBS Lett, 2000 Dec 29. PMID 11150526
  2. Germ cell-specific gene 1 targets testis-specific poly(A) polymerase to the endoplasmic reticulum through protein-protein interactions. Choi HS, et al. FEBS Lett, 2008 Apr 9. PMID 18325338
  3. Means to an end: mechanisms of alternative polyadenylation of messenger RNA precursors. Gruber AR, et al. Wiley Interdiscip Rev RNA, 2014 Mar-Apr. PMID 24243805, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
poly(A) polymerase beta
Names
poly (A) polymerase beta (testis specific)
NP_001012020.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012020.2 → NP_001012020.1  poly(A) polymerase beta

    See identical proteins and their annotated locations for NP_001012020.1

    Status: VALIDATED

    Source sequence(s)
    BC079046, CR458765
    UniProtKB/TrEMBL
    Q6AYH1
    Related
    ENSRNOP00000105823.1, ENSRNOT00000156880.1
    Conserved Domains (3) summary
    PTZ00418
    Location:10 → 569
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:367 → 508
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:22 → 364
    PAP_central; Poly(A) polymerase central domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    17157757..17160103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials