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Iqce IQ motif containing E [ Rattus norvegicus (Norway rat) ]

Gene ID: 304318, updated on 2-Nov-2024

Summary

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Official Symbol
Iqceprovided by RGD
Official Full Name
IQ motif containing Eprovided by RGD
Primary source
RGD:1311349
See related
EnsemblRapid:ENSRNOG00000001241 AllianceGenome:RGD:1311349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311349
Summary
Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; protein localization to motile cilium; and regulation of smoothened signaling pathway. Predicted to be located in ciliary membrane and cytoplasmic side of plasma membrane. Predicted to be part of plasma membrane protein complex. Orthologous to human IQCE (IQ motif containing E). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 102.7), Kidney (RPKM 27.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Iqce in Genome Data Viewer
Location:
12q11
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (19057060..19096626)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (13943290..13982708)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (16030607..16069872)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha 12 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene tweety family member 3 Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exome sequencing revealed a splice site variant in the IQCE gene underlying post-axial polydactyly type A restricted to lower limb. Umair M, et al. Eur J Hum Genet, 2017 Aug. PMID 28488682, Free PMC Article
  2. EFCAB7 and IQCE regulate hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia. Pusapati GV, et al. Dev Cell, 2014 Mar 10. PMID 24582806, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in limb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to motile cilium ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of plasma membrane protein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
IQ domain-containing protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432060.1 → NP_001418989.1  IQ domain-containing protein E isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6B1N9

  2. NM_001432061.1 → NP_001418990.1  IQ domain-containing protein E isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D3ZUL9

  3. NM_001432062.1 → NP_001418991.1  IQ domain-containing protein E isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K1R7

  4. NM_001432064.1 → NP_001418993.1  IQ domain-containing protein E isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  5. NM_001432065.1 → NP_001418994.1  IQ domain-containing protein E isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  6. NM_001432066.1 → NP_001418995.1  IQ domain-containing protein E isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  7. NM_001432067.1 → NP_001418996.1  IQ domain-containing protein E isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  8. NM_001432068.1 → NP_001418997.1  IQ domain-containing protein E isoform 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  9. NM_001432069.1 → NP_001418998.1  IQ domain-containing protein E isoform 9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  10. NM_001432070.1 → NP_001418999.1  IQ domain-containing protein E isoform 10

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  11. NM_001432071.1 → NP_001419000.1  IQ domain-containing protein E isoform 11

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  12. NM_001432072.1 → NP_001419001.1  IQ domain-containing protein E isoform 12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  13. NM_001432073.1 → NP_001419002.1  IQ domain-containing protein E isoform 13

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  14. NM_001432074.1 → NP_001419003.1  IQ domain-containing protein E isoform 14

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  15. NM_001432075.1 → NP_001419004.1  IQ domain-containing protein E isoform 15

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

  16. NM_001432076.1 → NP_001419005.1  IQ domain-containing protein E isoform 16

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    19057060..19096626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598488.3 → XP_017453977.1  IQ domain-containing protein E isoform X1

  2. XM_017598489.3 → XP_017453978.1  IQ domain-containing protein E isoform X3

  3. XM_017598490.3 → XP_017453979.1  IQ domain-containing protein E isoform X5

  4. XM_006248962.5 → XP_006249024.1  IQ domain-containing protein E isoform X2

    See identical proteins and their annotated locations for XP_006249024.1

    Conserved Domains (3) summary
    smart00015
    Location:561 → 581
    IQ; Calmodulin-binding motif
    pfam16043
    Location:423 → 477
    DUF4795; Domain of unknown function (DUF4795)
    pfam16046
    Location:347 → 478
    FAM76; FAM76 protein

  5. XM_063271863.1 → XP_063127933.1  IQ domain-containing protein E isoform X4

    Related
    ENSRNOP00000094917.1, ENSRNOT00000117335.2

  6. XM_221965.10 → XP_221965.5  IQ domain-containing protein E isoform X6

    See identical proteins and their annotated locations for XP_221965.5

    UniProtKB/TrEMBL
    D4ADQ3
    Related
    ENSRNOP00000040350.5, ENSRNOT00000051565.8
    Conserved Domains (3) summary
    smart00015
    Location:561 → 581
    IQ; Calmodulin-binding motif
    pfam16043
    Location:423 → 477
    DUF4795; Domain of unknown function (DUF4795)
    pfam16046
    Location:347 → 478
    FAM76; FAM76 protein

  7. XM_017598491.3 → XP_017453980.1  IQ domain-containing protein E isoform X7

  8. XM_063271865.1 → XP_063127935.1  IQ domain-containing protein E isoform X9

  9. XM_063271866.1 → XP_063127936.1  IQ domain-containing protein E isoform X12

  10. XM_063271864.1 → XP_063127934.1  IQ domain-containing protein E isoform X8

  11. XM_039089960.2 → XP_038945888.1  IQ domain-containing protein E isoform X10

    Related
    ENSRNOP00000111353.1, ENSRNOT00000130050.1
    Conserved Domains (2) summary
    smart00015
    Location:516 → 536
    IQ; Calmodulin-binding motif
    COG1196
    Location:167 → 465
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  12. XM_063271867.1 → XP_063127937.1  IQ domain-containing protein E isoform X13

  13. XM_039089961.2 → XP_038945889.1  IQ domain-containing protein E isoform X17

    Conserved Domains (2) summary
    smart00015
    Location:563 → 584
    IQ; Calmodulin-binding motif
    COG1196
    Location:212 → 510
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  14. XM_063271870.1 → XP_063127940.1  IQ domain-containing protein E isoform X18

  15. XM_017598492.3 → XP_017453981.1  IQ domain-containing protein E isoform X11

    Related
    ENSRNOP00000001667.8, ENSRNOT00000001667.8

  16. XM_017598494.3 → XP_017453983.1  IQ domain-containing protein E isoform X19

  17. XM_063271872.1 → XP_063127942.1  IQ domain-containing protein E isoform X21

  18. XM_017598493.3 → XP_017453982.1  IQ domain-containing protein E isoform X14

  19. XM_063271868.1 → XP_063127938.1  IQ domain-containing protein E isoform X15

  20. XM_063271869.1 → XP_063127939.1  IQ domain-containing protein E isoform X16

  21. XM_063271871.1 → XP_063127941.1  IQ domain-containing protein E isoform X20

Nucleotide Protein Strain
Heading Accession and Version

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