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Anapc7 anaphase promoting complex subunit 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304490, updated on 2-Nov-2024

Summary

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Official Symbol
Anapc7provided by RGD
Official Full Name
anaphase promoting complex subunit 7provided by RGD
Primary source
RGD:1311927
See related
EnsemblRapid:ENSRNOG00000001283 AllianceGenome:RGD:1311927
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme-substrate adaptor activity and protein phosphatase binding activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be located in heterochromatin; nucleus; and spindle. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC7 (anaphase promoting complex subunit 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 84.4), Heart (RPKM 64.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Anapc7 in Genome Data Viewer
Location:
12q16
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (39793518..39821614, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34131214..34160819, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39613898..39641999, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 81 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Neighboring gene ribosomal protein L38, pseudogene 4 Neighboring gene uncharacterized LOC108352447 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene actin related protein 2/3 complex, subunit 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article
  2. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Song MS, et al. Cell, 2011 Jan 21. PMID 21241890, Free PMC Article
  3. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Jin L, et al. Cell, 2008 May 16. PMID 18485873, Free PMC Article
  4. Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C. Dube P, et al. Mol Cell, 2005 Dec 22. PMID 16364912
  5. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein branched polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein branched polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107142.1 → NP_001100612.1  anaphase-promoting complex subunit 7

    See identical proteins and their annotated locations for NP_001100612.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A0A8I6GMR3, A6J196, D3ZIT4
    Conserved Domains (2) summary
    TIGR02917
    Location:208 → 509
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:338 → 368
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    39793518..39821614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249365.4 → XP_006249427.2  anaphase-promoting complex subunit 7 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GMR3, A6J196, D3ZIT4
    Related
    ENSRNOP00000001729.4, ENSRNOT00000001729.6
    Conserved Domains (2) summary
    TIGR02917
    Location:208 → 509
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:338 → 368
    TPR; TPR repeat [structural motif]

  2. XM_039089466.2 → XP_038945394.1  anaphase-promoting complex subunit 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GMR3
    Conserved Domains (2) summary
    TIGR02917
    Location:141 → 442
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:271 → 301
    TPR; TPR repeat [structural motif]

  3. XM_017598334.3 → XP_017453823.1  anaphase-promoting complex subunit 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GMR3
    Conserved Domains (2) summary
    TIGR02917
    Location:141 → 442
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:271 → 301
    TPR; TPR repeat [structural motif]

  4. XM_039089467.2 → XP_038945395.1  anaphase-promoting complex subunit 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GMR3
    Conserved Domains (2) summary
    TIGR02917
    Location:101 → 402
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:231 → 261
    TPR; TPR repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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