Sirt4 sirtuin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sirt4provided by RGD
Official Full Name: sirtuin 4provided by RGD
Primary source: RGD:1310413
See related: EnsemblRapid:ENSRNOG00000001151 AllianceGenome:RGD:1310413
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including NAD+-protein poly-ADP-ribosyltransferase activity; acyltransferase activity, transferring groups other than amino-acyl groups; and protein lysine deacetylase activity. Involved in cellular response to hypoxia; negative regulation of cardiac muscle cell apoptotic process; and negative regulation of protein processing involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial matrix. Biomarker of metabolic dysfunction-associated steatotic liver disease. Orthologous to human SIRT4 (sirtuin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 21.6), Liver (RPKM 18.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (46785852..46800179)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (41125533..41139440)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (46862358..46876593)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SIRT4 regulates rat dental papilla cell differentiation by promoting mitochondrial functions.
Title: SIRT4 regulates rat dental papilla cell differentiation by promoting mitochondrial functions.
Physiological profile regulation during weight gain and loss by ovariectomized females: importance of SIRT1 and SIRT4.
Title: Physiological profile regulation during weight gain and loss by ovariectomized females: importance of SIRT1 and SIRT4.
the association between recovery of olfactory function and the increase in bulbar SIRT1 and SIRT4 expression, is reported.
Title: Recovery of Olfactory Function After Excitotoxic Lesion of the Olfactory Bulbs Is Associated with Increases in Bulbar SIRT1 and SIRT4 Expressions.
Sirtuin 4 regulates inflammation-mediated Leydig cell dysfunction.
Title: Sirtuin 4 Regulates Lipopolysaccharide Mediated Leydig Cell Dysfunction.
Shortterm caloric restriction may activate SIRT1 as well as SIRT24 and 7 expression in cardiomyocytes in vivo and in vitro.
Title: Short‑term calorie restriction activates SIRT1‑4 and ‑7 in cardiomyocytes in vivo and in vitro.
SIRT4 expression could affect the ratio of pro-caspase 9/caspase 9 or pro-caspase 3/caspase 3, and change Bax translocation, which in turn alter the development of H9c2 cell apoptosis.
Title: SIRT4 prevents hypoxia-induced apoptosis in H9c2 cardiomyoblast cells.
We find that SIRT4 and GDH1 overexpression play antagonistic roles in regulating gliogenesis
Title: Glutamate dehydrogenase 1 and SIRT4 regulate glial development.
SIRT1 and SIRT4 were both involved in the development of insulin resistance and nonalcoholic fatty liver disease.
Title: Calorie restriction on insulin resistance and expression of SIRT1 and SIRT4 in rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein biotinidase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein lipoamidase activity	ISO Inferred from Sequence Orthology more info
NOT enables NAD-dependent protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables NAD-dependent protein lysine deacetylase activity	ISO Inferred from Sequence Orthology more info
enables histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipoamidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in epigenetic regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein processing involved in protein targeting to mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine deacetylation	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-lysine deacetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein deacetylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of glutamine family amino acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of pyruvate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of pyruvate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
involved_in tricarboxylic acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

Names: NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4

NP_001100617.2

EC 2.3.1.-

EC 2.3.1.286

XP_063127419.1

EC 2.3.1.-

EC 2.3.1.286

XP_063127420.1

EC 2.3.1.-

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107147.2 → NP_001100617.2 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A0A0G2K6D8, A6J1T8, G3V641

Related

ENSRNOP00000073772.2, ENSRNOT00000084421.3

Conserved Domains (1) summary

cd01409
Location:52 → 313

SIRT4; Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

46785852..46800179

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271349.1 → XP_063127419.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A0G2K6D8
XM_063271350.1 → XP_063127420.1 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial isoform X2