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Oasl 2'-5'-oligoadenylate synthetase-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 304545, updated on 28-Oct-2024

Summary

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Official Symbol
Oaslprovided by RGD
Official Full Name
2'-5'-oligoadenylate synthetase-likeprovided by RGD
Primary source
RGD:1308586
See related
EnsemblRapid:ENSRNOG00000001187 AllianceGenome:RGD:1308586
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Oasl1
Summary
Predicted to enable DNA binding activity and double-stranded RNA binding activity. Predicted to be involved in several processes, including innate immune response; interleukin-27-mediated signaling pathway; and positive regulation of RIG-I signaling pathway. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in cytosol; membrane; and nucleoplasm. Orthologous to human OASL (2'-5'-oligoadenylate synthetase like). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 77.9), Spleen (RPKM 54.0) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Oasl in Genome Data Viewer
Location:
12q16
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47343551..47356509, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41682900..41695641, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47444138..47456680, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene signal peptide peptidase like 3 Neighboring gene HNF1 homeobox A Neighboring gene similar to human chromosome 12 open reading frame 43 Neighboring gene uncharacterized LOC134481304 Neighboring gene uncharacterized LOC120096007 Neighboring gene RIKEN cDNA 4930519G04 gene like Neighboring gene 2'-5' oligoadenylate synthetase-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. 2',5'-Oligoadenylate synthetase-like gene highly induced by hepatitis C virus infection in human liver is inhibitory to viral replication in vitro. Ishibashi M, et al. Biochem Biophys Res Commun, 2010 Feb 12. PMID 20074559
  2. Molecular cloning and characterization of two related and interferon-induced 56-kDa and 30-kDa proteins highly similar to 2'-5' oligoadenylate synthetase. Rebouillat D, et al. Eur J Biochem, 1998 Oct 15. PMID 9826176
  3. The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain. Marques J, et al. J Gen Virol, 2008 Nov. PMID 18931074
  4. Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family. Eskildsen S, et al. Nucleic Acids Res, 2003 Jun 15. PMID 12799444, Free PMC Article
  5. Genomic structure of the mouse 2',5'-oligoadenylate synthetase gene family. Kakuta S, et al. J Interferon Cytokine Res, 2002 Sep. PMID 12396720

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables 2'-5'-oligoadenylate synthetase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables 2'-5'-oligoadenylate synthetase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-27-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-27-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
2'-5'-oligoadenylate synthase-like protein 1
Names
2'-5' oligoadenylate synthetase-like 1
59 kDa 2'-5'-oligoadenylate synthase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009681.1 → NP_001009681.1  2'-5'-oligoadenylate synthase-like protein 1

    See identical proteins and their annotated locations for NP_001009681.1

    Status: PROVISIONAL

    Source sequence(s)
    AY227756
    UniProtKB/Swiss-Prot
    G3V645, Q5MYW3
    Related
    ENSRNOP00000001570.4, ENSRNOT00000001570.6
    Conserved Domains (5) summary
    cd05400
    Location:29 → 209
    NT_2-5OAS_ClassI-CCAase; Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme
    smart00213
    Location:431 → 499
    UBQ; Ubiquitin homologues
    pfam00240
    Location:436 → 502
    ubiquitin; Ubiquitin family
    pfam10421
    Location:167 → 347
    OAS1_C; 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus
    cl00155
    Location:351 → 430
    UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    47343551..47356509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271353.1 → XP_063127423.1  2'-5'-oligoadenylate synthase-like protein 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3V645.1 GenPept UniProtKB/Swiss-Prot:G3V645

Gene LinkOut

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