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Tchp trichoplein, keratin filament binding [ Rattus norvegicus (Norway rat) ]

Gene ID: 304547, updated on 28-Oct-2024

Summary

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Official Symbol
Tchpprovided by RGD
Official Full Name
trichoplein, keratin filament bindingprovided by RGD
Primary source
RGD:1310813
See related
EnsemblRapid:ENSRNOG00000001191 AllianceGenome:RGD:1310813
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310813
Summary
Predicted to be involved in apoptotic process; negative regulation of cell growth; and negative regulation of cilium assembly. Predicted to be located in several cellular components, including apical cortex; centrosome; and desmosome. Predicted to be part of ciliary transition fiber. Predicted to be active in keratin filament. Orthologous to human TCHP (trichoplein keratin filament binding). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Testes (RPKM 184.1), Thymus (RPKM 88.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tchp in Genome Data Viewer
Location:
12q16
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (47538520..47553895, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41877888..41893264, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47638278..47653602, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 13a Neighboring gene GIT ArfGAP 2 Neighboring gene uncharacterized LOC102547088 Neighboring gene glycolipid transfer protein Neighboring gene transient receptor potential cation channel, subfamily V, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MITOSTATIN, a putative tumor suppressor on chromosome 12q24.1, is downregulated in human bladder and breast cancer. Vecchione A, et al. Oncogene, 2009 Jan 15. PMID 18931701, Free PMC Article
  2. Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. Ibi M, et al. J Cell Sci, 2011 Mar 15. PMID 21325031
  3. Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension. Kasahara K, et al. Nat Commun, 2014 Oct 1. PMID 25270598, Free PMC Article
  4. Identification of trichoplein, a novel keratin filament-binding protein. Nishizawa M, et al. J Cell Sci, 2005 Mar 1. PMID 15731013
  5. Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis. Veleri S, et al. Nat Commun, 2014 Jun 20. PMID 24947469, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical cortex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
part_of ciliary transition fiber ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in desmosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
trichoplein keratin filament-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191666.1 → NP_001178595.1  trichoplein keratin filament-binding protein

    See identical proteins and their annotated locations for NP_001178595.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J1Z0, D3ZY42
    Conserved Domains (1) summary
    pfam13868
    Location:142 → 481
    TPH; Trichohyalin-plectin-homology domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    47538520..47553895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249451.4 → XP_006249513.1  trichoplein keratin filament-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006249513.1

    UniProtKB/TrEMBL
    A6J1Z0, D3ZY42
    Conserved Domains (1) summary
    pfam13868
    Location:142 → 481
    TPH; Trichohyalin-plectin-homology domain

  2. XM_006249452.4 → XP_006249514.1  trichoplein keratin filament-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006249514.1

    UniProtKB/TrEMBL
    A6J1Z0, D3ZY42
    Related
    ENSRNOP00000001577.6, ENSRNOT00000001577.9
    Conserved Domains (1) summary
    pfam13868
    Location:142 → 481
    TPH; Trichohyalin-plectin-homology domain

  3. XM_039089503.2 → XP_038945431.1  trichoplein keratin filament-binding protein isoform X2

    UniProtKB/TrEMBL
    A6J1Z0
    Conserved Domains (1) summary
    pfam13868
    Location:80 → 419
    TPH; Trichohyalin-plectin-homology domain
Nucleotide Protein Strain
Heading Accession and Version

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