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Sez6l seizure related 6 homolog like [ Rattus norvegicus (Norway rat) ]

Gene ID: 304554, updated on 2-Nov-2024

Summary

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Official Symbol
Sez6lprovided by RGD
Official Full Name
seizure related 6 homolog likeprovided by RGD
Primary source
RGD:1563628
See related
EnsemblRapid:ENSRNOG00000025612 AllianceGenome:RGD:1563628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563628
Summary
Predicted to be involved in regulation of protein kinase C signaling and synapse maturation. Predicted to act upstream of or within adult locomotory behavior and cerebellar Purkinje cell layer development. Predicted to be active in several cellular components, including glutamatergic synapse; neuronal cell body; and postsynaptic membrane. Orthologous to human SEZ6L (seizure related 6 homolog like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 102.5), Testes (RPKM 11.6) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sez6l in Genome Data Viewer
Location:
12q16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (49725330..49882222)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (44064901..44221814)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (50090345..50243020)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481310 Neighboring gene myosin XVIIIb Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil domain containing 121 like 2 Neighboring gene coiled-coil domain-containing protein 121-like Neighboring gene aspartate beta-hydroxylase domain containing 2 Neighboring gene HPS4, biogenesis of lysosomal organelles complex 3 subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. Miyazaki T, et al. FEBS Lett, 2006 Jul 24. PMID 16814779
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cerebellar Purkinje cell layer development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase C signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in synapse maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synapse maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
seizure 6-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415748.1 → NP_001402677.1  seizure 6-like protein isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    Related
    ENSRNOP00000078248.1, ENSRNOT00000094109.2

  2. NM_001415749.1 → NP_001402678.1  seizure 6-like protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    D4AD89
    Related
    ENSRNOP00000038097.7, ENSRNOT00000032193.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    49725330..49882222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001134538.1: Suppressed sequence

    Description
    NM_001134538.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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