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Dtx2 deltex E3 ubiquitin ligase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304591, updated on 17-Aug-2024

Summary

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Official Symbol
Dtx2provided by RGD
Official Full Name
deltex E3 ubiquitin ligase 2provided by RGD
Primary source
RGD:1561790
See related
EnsemblRapid:ENSRNOG00000001432 AllianceGenome:RGD:1561790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in Notch signaling pathway and protein ubiquitination. Predicted to be located in nuclear membrane. Predicted to be active in nucleoplasm. Orthologous to human DTX2 (deltex E3 ubiquitin ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 51.4), Thymus (RPKM 49.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dtx2 in Genome Data Viewer
Location:
12q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26279899..26319541, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (20643289..20682908, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23687958..23727594, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uroplakin 3B like 1 Neighboring gene uncharacterized LOC120095913 Neighboring gene uroplakin 3B Neighboring gene U6 spliceosomal RNA Neighboring gene zona pellucida glycoprotein 3 Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Kishi N, et al. Int J Dev Neurosci, 2001 Feb. PMID 11226752
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase DTX2
Names
deltex 2 homolog
deltex 2, E3 ubiquitin ligase
deltex homolog 2
protein deltex-2
NP_001100627.1
XP_006249221.1
XP_038945454.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107157.2 → NP_001100627.1  probable E3 ubiquitin-protein ligase DTX2

    See identical proteins and their annotated locations for NP_001100627.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6J094, B2RYD5, G3V658
    Related
    ENSRNOP00000001950.5, ENSRNOT00000001950.8
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    PHA03247
    Location:204 → 392
    PHA03247; large tegument protein UL36; Provisional
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:477 → 611
    DTC; Deltex C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    26279899..26319541 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249159.4 → XP_006249221.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    See identical proteins and their annotated locations for XP_006249221.1

    UniProtKB/TrEMBL
    A0A8I5ZTQ2, A6J092, B2RYD5
    Related
    ENSRNOP00000080750.1, ENSRNOT00000110093.2
    Conserved Domains (3) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:432 → 564
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd00162
    Location:362 → 425
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. XM_039089526.2 → XP_038945454.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    A6J094, B2RYD5, G3V658
    Conserved Domains (4) summary
    smart00678
    Location:21 → 105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    PHA03247
    Location:204 → 392
    PHA03247; large tegument protein UL36; Provisional
    cd16672
    Location:408 → 479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:477 → 611
    DTC; Deltex C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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