Asf1b anti-silencing function 1B histone chaperone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asf1bprovided by RGD
Official Full Name: anti-silencing function 1B histone chaperoneprovided by RGD
Primary source: RGD:1304918
See related: EnsemblRapid:ENSRNOG00000005115 AllianceGenome:RGD:1304918
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable histone binding activity and histone chaperone activity. Predicted to be involved in DNA replication-dependent chromatin assembly. Predicted to act upstream of or within blastocyst hatching and nucleosome assembly. Predicted to be located in chromatin and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human ASF1B (anti-silencing function 1B histone chaperone). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 147.3), Spleen (RPKM 69.9) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (41085786..41100352, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (24181024..24195604, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25077918..25092491)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables histone chaperone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blastocyst hatching	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nucleosome assembly	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone chaperone ASF1B

Names: ASF1 anti-silencing function 1 homolog B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107160.1 → NP_001100630.1 histone chaperone ASF1B

See identical proteins and their annotated locations for NP_001100630.1

Status: PROVISIONAL

Source sequence(s)

CH473972

UniProtKB/TrEMBL

A0A8I5ZUP3, A6IYC4, B0BN69, F7EWU6

Related

ENSRNOP00000006964.6, ENSRNOT00000006964.7

Conserved Domains (1) summary

pfam04729
Location:1 → 154

ASF1_hist_chap; ASF1 like histone chaperone

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

41085786..41100352 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097681.2 → XP_038953609.1 histone chaperone ASF1B isoform X1

Conserved Domains (1) summary

pfam04729
Location:1 → 84

ASF1_hist_chap; ASF1 like histone chaperone