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Brme1 break repair meiotic recombinase recruitment factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304654, updated on 17-Aug-2024

Summary

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Official Symbol
Brme1provided by RGD
Official Full Name
break repair meiotic recombinase recruitment factor 1provided by RGD
Primary source
RGD:1306072
See related
EnsemblRapid:ENSRNOG00000025796 AllianceGenome:RGD:1306072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306072
Summary
Predicted to be involved in meiosis I and spermatogenesis. Predicted to be located in chromosome. Orthologous to human BRME1 (break repair meiotic recombinase recruitment factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 43.3), Adrenal (RPKM 29.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40894821..40916506, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23990049..24011774, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (25262064..25283786)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene microRNA 181d Neighboring gene nanos C2HC-type zinc finger 3 Neighboring gene coiled-coil and C2 domain containing 1A Neighboring gene podocan-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in double-strand break repair involved in meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in female meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in male meiosis I ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to site of double-strand break ISO
Inferred from Sequence Orthology
more info
  
involved_in reciprocal meiotic recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
break repair meiotic recombinase recruitment factor 1
Names
uncharacterized protein C19orf57 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001400966.1 → NP_001387895.1  break repair meiotic recombinase recruitment factor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A8I5ZR08
    Related
    ENSRNOP00000029954.7, ENSRNOT00000030658.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    40894821..40916506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277962.1 → XP_063134032.1  break repair meiotic recombinase recruitment factor 1 isoform X5

    UniProtKB/TrEMBL
    A6IYA6

  2. XM_006255331.4 → XP_006255393.1  break repair meiotic recombinase recruitment factor 1 isoform X4

    See identical proteins and their annotated locations for XP_006255393.1

    UniProtKB/TrEMBL
    A6IYA6, F1M7E8
    Related
    ENSRNOP00000105447.1, ENSRNOT00000171684.1
    Conserved Domains (1) summary
    pfam15710
    Location:1 → 616
    DUF4671; Domain of unknown function (DUF4671)

  3. XM_063277961.1 → XP_063134031.1  break repair meiotic recombinase recruitment factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZR08

  4. XM_039098080.2 → XP_038954008.1  break repair meiotic recombinase recruitment factor 1 isoform X7

    UniProtKB/TrEMBL
    A6IYA6
    Conserved Domains (1) summary
    pfam15710
    Location:4 → 582
    DUF4671; Domain of unknown function (DUF4671)

  5. XM_039098077.2 → XP_038954005.1  break repair meiotic recombinase recruitment factor 1 isoform X7

    UniProtKB/TrEMBL
    A6IYA6
    Related
    ENSRNOP00000079476.1, ENSRNOT00000109548.2
    Conserved Domains (1) summary
    pfam15710
    Location:4 → 582
    DUF4671; Domain of unknown function (DUF4671)

  6. XM_039098074.2 → XP_038954002.1  break repair meiotic recombinase recruitment factor 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZU35
    Related
    ENSRNOP00000108359.1, ENSRNOT00000165748.1
    Conserved Domains (1) summary
    pfam15710
    Location:60 → 639
    DUF4671; Domain of unknown function (DUF4671)

  7. XM_017601425.3 → XP_017456914.1  break repair meiotic recombinase recruitment factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y9Q2, A0A8I5ZU35
    Conserved Domains (1) summary
    pfam15710
    Location:60 → 670
    DUF4671; Domain of unknown function (DUF4671)

  8. XM_039098073.2 → XP_038954001.1  break repair meiotic recombinase recruitment factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y9Q2, A0A8I5ZU35
    Conserved Domains (1) summary
    pfam15710
    Location:60 → 670
    DUF4671; Domain of unknown function (DUF4671)

  9. XM_063277964.1 → XP_063134034.1  break repair meiotic recombinase recruitment factor 1 isoform X7

    UniProtKB/TrEMBL
    A6IYA6

  10. XM_063277960.1 → XP_063134030.1  break repair meiotic recombinase recruitment factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y9Q2, A0A8I5ZU35

  11. XM_063277965.1 → XP_063134035.1  break repair meiotic recombinase recruitment factor 1 isoform X7

    UniProtKB/TrEMBL
    A6IYA6
    Related
    ENSRNOP00000077742.1, ENSRNOT00000115206.2

  12. XM_063277963.1 → XP_063134033.1  break repair meiotic recombinase recruitment factor 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZU35

RNA

  1. XR_005496718.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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