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Epb41l5 erythrocyte membrane protein band 4.1 like 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304733, updated on 17-Aug-2024

Summary

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Official Symbol
Epb41l5provided by RGD
Official Full Name
erythrocyte membrane protein band 4.1 like 5provided by RGD
Primary source
RGD:1311366
See related
EnsemblRapid:ENSRNOG00000002538 AllianceGenome:RGD:1311366
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Epb4.1l5
Summary
Predicted to enable protein domain specific binding activity. Predicted to be involved in actomyosin structure organization and epithelial to mesenchymal transition. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic foregut morphogenesis; and mesoderm morphogenesis. Predicted to be located in several cellular components, including focal adhesion; nucleoplasm; and ruffle membrane. Predicted to be active in cytoskeleton. Orthologous to human EPB41L5 (erythrocyte membrane protein band 4.1 like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 255.7), Lung (RPKM 220.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q11
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (33221705..33321400, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (30670792..30770213, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (35622472..35673449, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 185B Neighboring gene protein tyrosine phosphatase, non-receptor type 4 Neighboring gene uncharacterized LOC134481550 Neighboring gene ankyrin repeat domain 49, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Epithelial cell shape is regulated by Lulu proteins via myosin-II. Nakajima H, et al. J Cell Sci, 2010 Feb 15. PMID 20103536
  2. Left-right patterning in the mouse requires Epb4.1l5-dependent morphogenesis of the node and midline. Lee JD, et al. Dev Biol, 2010 Oct 15. PMID 20678497, Free PMC Article
  3. The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Lee JD, et al. Development, 2007 Jun. PMID 17507402
  4. EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. Hirano M, et al. J Cell Biol, 2008 Sep 22. PMID 18794329, Free PMC Article
  5. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. García-García MJ, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15755804, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109531

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apical constriction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within axial mesoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within axial mesoderm morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ectoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic foregut morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within left/right axis specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mesoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mesoderm migration involved in gastrulation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural plate morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within paraxial mesoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somite rostral/caudal axis specification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somitogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within substrate-dependent cell migration, cell attachment to substrate ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within unidimensional cell growth ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
band 4.1-like protein 5
Names
erythrocyte protein band 4.1-like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012023.1 → NP_001012023.1  band 4.1-like protein 5 isoform 2

    See identical proteins and their annotated locations for NP_001012023.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090012
    UniProtKB/TrEMBL
    D3ZK45
    Related
    ENSRNOP00000045431.4, ENSRNOT00000042862.7
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl28922
    Location:41 → 126
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. NM_001401160.1 → NP_001388089.1  band 4.1-like protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q5FVG2
    Related
    ENSRNOP00000106343.1, ENSRNOT00000131496.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    33221705..33321400 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090680.2 → XP_038946608.1  band 4.1-like protein 5 isoform X2

    UniProtKB/Swiss-Prot
    Q5FVG2
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl40461
    Location:477 → 510
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  2. XM_039090673.2 → XP_038946601.1  band 4.1-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVG2
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl40461
    Location:477 → 510
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  3. XM_039090679.2 → XP_038946607.1  band 4.1-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVG2
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl40461
    Location:477 → 510
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  4. XM_039090678.2 → XP_038946606.1  band 4.1-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVG2
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl40461
    Location:477 → 510
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  5. XM_039090675.2 → XP_038946603.1  band 4.1-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVG2
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl40461
    Location:477 → 510
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  6. XM_063272230.1 → XP_063128300.1  band 4.1-like protein 5 isoform X2

    UniProtKB/Swiss-Prot
    Q5FVG2

  7. XM_039090671.2 → XP_038946599.1  band 4.1-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVG2
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl40461
    Location:477 → 510
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  8. XM_039090676.2 → XP_038946604.1  band 4.1-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVG2
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl40461
    Location:477 → 510
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  9. XM_039090677.2 → XP_038946605.1  band 4.1-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVG2
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl40461
    Location:477 → 510
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  10. XM_039090674.2 → XP_038946602.1  band 4.1-like protein 5 isoform X1

    UniProtKB/Swiss-Prot
    Q5FVG2
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl40461
    Location:477 → 510
    ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins

  11. XM_063272234.1 → XP_063128304.1  band 4.1-like protein 5 isoform X3

    UniProtKB/TrEMBL
    D3ZK45

  12. XM_063272233.1 → XP_063128303.1  band 4.1-like protein 5 isoform X3

    UniProtKB/TrEMBL
    D3ZK45

  13. XM_063272232.1 → XP_063128302.1  band 4.1-like protein 5 isoform X3

    UniProtKB/TrEMBL
    D3ZK45

  14. XM_063272231.1 → XP_063128301.1  band 4.1-like protein 5 isoform X3

    UniProtKB/TrEMBL
    D3ZK45

  15. XM_039090681.2 → XP_038946609.1  band 4.1-like protein 5 isoform X3

    UniProtKB/TrEMBL
    D3ZK45
    Conserved Domains (4) summary
    smart00295
    Location:44 → 235
    B41; Band 4.1 homologues
    cd13186
    Location:231 → 324
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:337 → 378
    FA; FERM adjacent (FA)
    cl28922
    Location:41 → 126
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  16. XM_063272235.1 → XP_063128305.1  band 4.1-like protein 5 isoform X3

    UniProtKB/TrEMBL
    D3ZK45

  17. XM_063272236.1 → XP_063128306.1  band 4.1-like protein 5 isoform X4

    UniProtKB/TrEMBL
    D3ZK45
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FVG2.2 GenPept UniProtKB/Swiss-Prot:Q5FVG2

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