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Zranb3 zinc finger RANBP2-type containing 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304761, updated on 2-Nov-2024

Summary

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Official Symbol
Zranb3provided by RGD
Official Full Name
zinc finger RANBP2-type containing 3provided by RGD
Primary source
RGD:1564952
See related
EnsemblRapid:ENSRNOG00000003979 AllianceGenome:RGD:1564952
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564952
Summary
Predicted to enable ATP-dependent DNA/DNA annealing activity; DNA endonuclease activity; and K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Predicted to be located in nucleoplasm. Predicted to be active in nuclear replication fork. Orthologous to human ZRANB3 (zinc finger RANBP2-type containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 59.6), Thymus (RPKM 33.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zranb3 in Genome Data Viewer
Location:
13q13
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (41993110..42148298, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (39440653..39595782, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (44661375..44812430, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 19 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene RAB3 GTPase activating protein catalytic subunit 1 Neighboring gene microRNA 3473 Neighboring gene C-x(9)-C motif containing 1 like 1 Neighboring gene male-enhanced antigen 1-like Neighboring gene R3H domain containing 1 Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif. Yusufzai T, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21078962, Free PMC Article
  2. ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. Weston R, et al. Genes Dev, 2012 Jul 15. PMID 22759634, Free PMC Article
  3. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Ciccia A, et al. Mol Cell, 2012 Aug 10. PMID 22704558, Free PMC Article
  4. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Yuan J, et al. Mol Cell, 2012 Aug 10. PMID 22705370, Free PMC Article
  5. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA rewinding ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
involved_in replication fork reversal ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nuclear replication fork IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear replication fork ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA annealing helicase and endonuclease ZRANB3
Names
zinc finger, RAN-binding domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    41993110..42148298 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249701.5 → XP_006249763.1  DNA annealing helicase and endonuclease ZRANB3 isoform X1

    UniProtKB/TrEMBL
    D3ZDS8
    Related
    ENSRNOP00000103776.1, ENSRNOT00000125485.1
    Conserved Domains (6) summary
    smart00547
    Location:648 → 670
    ZnF_RBZ; Zinc finger domain
    smart00487
    Location:56 → 239
    DEXDc; DEAD-like helicases superfamily
    cd00046
    Location:82 → 217
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00085
    Location:1014 → 1053
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:648 → 667
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00271
    Location:357 → 462
    Helicase_C; Helicase conserved C-terminal domain

  2. XM_008769510.4 → XP_008767732.1  DNA annealing helicase and endonuclease ZRANB3 isoform X4

    Conserved Domains (5) summary
    smart00547
    Location:266 → 288
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:10 → 122
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd00085
    Location:632 → 671
    HNHc; HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and ...
    sd00029
    Location:266 → 285
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00271
    Location:1 → 80
    Helicase_C; Helicase conserved C-terminal domain

  3. XM_063272740.1 → XP_063128810.1  DNA annealing helicase and endonuclease ZRANB3 isoform X2

  4. XM_039091286.2 → XP_038947214.1  DNA annealing helicase and endonuclease ZRANB3 isoform X3

    UniProtKB/TrEMBL
    A6IBW5
    Conserved Domains (4) summary
    smart00547
    Location:648 → 670
    ZnF_RBZ; Zinc finger domain
    COG0553
    Location:12 → 504
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    sd00029
    Location:648 → 667
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd18010
    Location:64 → 283
    DEXHc_HARP_SMARCAL1; DEXH-box helicase domain of SMARCAL1

  5. XM_063272741.1 → XP_063128811.1  DNA annealing helicase and endonuclease ZRANB3 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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