Dyrk3 dual specificity tyrosine phosphorylation regulated kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dyrk3provided by RGD
Official Full Name: dual specificity tyrosine phosphorylation regulated kinase 3provided by RGD
Primary source: RGD:1310924
See related: EnsemblRapid:ENSRNOG00000004870 AllianceGenome:RGD:1310924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including nuclear speck organization; protein phosphorylation; and regulation of intracellular signal transduction. Predicted to be located in several cellular components, including cytoplasmic stress granule; nuclear speck; and pericentriolar material. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 172.1), Spleen (RPKM 69.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (45146383..45157082, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (42594120..42604898, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (47906230..47916877, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear speck organization	IEA Inferred from Electronic Annotation more info
involved_in nuclear speck organization	ISO Inferred from Sequence Orthology more info
involved_in nuclear speck organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in organelle disassembly	ISO Inferred from Sequence Orthology more info
involved_in organelle disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell cycle G2/M phase transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell cycle G2/M phase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle G2/M phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in stress granule disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in stress granule disassembly	IEA Inferred from Electronic Annotation more info
involved_in stress granule disassembly	ISO Inferred from Sequence Orthology more info
involved_in stress granule disassembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	IEA Inferred from Electronic Annotation more info
located_in pericentriolar material	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 3

Names: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

NP_001019938.1

EC 2.7.12.1

XP_038946619.1

EC 2.7.12.1

XP_038946621.1

EC 2.7.12.1

XP_038946622.1

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024767.1 → NP_001019938.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform 1

See identical proteins and their annotated locations for NP_001019938.1

Status: PROVISIONAL

Source sequence(s)

BC097474

UniProtKB/Swiss-Prot

Q4V8A3

UniProtKB/TrEMBL

F1LN50

Related

ENSRNOP00000006502.5, ENSRNOT00000006502.7

Conserved Domains (2) summary

smart00220
Location:208 → 521

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14224
Location:142 → 521

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
NM_001430049.1 → NP_001416978.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6IC13, F1LN50
NM_001430050.1 → NP_001416979.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A6IC13, F1LN50
NM_001430051.1 → NP_001416980.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F1LN50
NM_001430052.1 → NP_001416981.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F1LN50
NM_001430053.1 → NP_001416982.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

F1LN50

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

45146383..45157082 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090693.2 → XP_038946621.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2

Conserved Domains (1) summary

cd14224
Location:60 → 439

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
XM_039090691.2 → XP_038946619.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

Conserved Domains (1) summary

cd14224
Location:107 → 486

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3
XM_039090694.2 → XP_038946622.1 dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2

Conserved Domains (1) summary

cd14224
Location:60 → 439

PKc_DYRK2_3; Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3