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Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 304794, updated on 2-Nov-2024

Summary

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Official Symbol
Rbbp5provided by RGD
Official Full Name
RB binding protein 5, histone lysine methyltransferase complex subunitprovided by RGD
Primary source
RGD:1305532
See related
EnsemblRapid:ENSRNOG00000021289 AllianceGenome:RGD:1305532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone binding activity and transcription cis-regulatory region binding activity. Predicted to be involved in response to estrogen and transcription initiation-coupled chromatin remodeling. Predicted to act upstream of or within DNA damage response. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Orthologous to human RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 131.5), Spleen (RPKM 103.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbbp5 in Genome Data Viewer
Location:
13q13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (46464389..46494244)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43912254..43939107)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (49250301..49277152)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domain family 2 Neighboring gene dual serine/threonine and tyrosine protein kinase Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane protein 81 Neighboring gene contactin 2 Neighboring gene neurofascin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland. Ginger MR, et al. Mol Endocrinol, 2001 Nov. PMID 11682629
  2. Identification of the MLL2 complex as a coactivator for estrogen receptor alpha. Mo R, et al. J Biol Chem, 2006 Jun 9. PMID 16603732
  3. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. Patel A, et al. J Biol Chem, 2009 Sep 4. PMID 19556245, Free PMC Article
  4. Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Yokoyama A, et al. Mol Cell Biol, 2004 Jul. PMID 15199122, Free PMC Article
  5. Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. Lee JH, et al. J Biol Chem, 2007 May 4. PMID 17355966

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1/2 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
  
part_of Set1C/COMPASS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retinoblastoma-binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107174.2 → NP_001100644.1  retinoblastoma-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001100644.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A6IC52, D3ZC01
    Related
    ENSRNOP00000031945.2, ENSRNOT00000036110.4
    Conserved Domains (3) summary
    PTZ00441
    Location:340 → 498
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:29 → 64
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:30 → 322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_001429997.1 → NP_001416926.1  retinoblastoma-binding protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  3. NM_001429998.1 → NP_001416927.1  retinoblastoma-binding protein 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  4. NM_001429999.1 → NP_001416928.1  retinoblastoma-binding protein 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    46464389..46494244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249775.5 → XP_006249837.1  retinoblastoma-binding protein 5 isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:29 → 64
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:30 → 322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_039090699.2 → XP_038946627.1  retinoblastoma-binding protein 5 isoform X4

    Conserved Domains (2) summary
    COG2319
    Location:38 → 321
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:29 → 64
    7WD40; WD40 repeat [structural motif]

  3. XM_017598792.3 → XP_017454281.1  retinoblastoma-binding protein 5 isoform X2

    Conserved Domains (3) summary
    PTZ00441
    Location:301 → 459
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    sd00039
    Location:30 → 67
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:34 → 283
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_063272287.1 → XP_063128357.1  retinoblastoma-binding protein 5 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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