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Ppp1r12b protein phosphatase 1, regulatory subunit 12B [ Rattus norvegicus (Norway rat) ]

Gene ID: 304813, updated on 10-Jul-2024

Summary

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Official Symbol
Ppp1r12bprovided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 12Bprovided by RGD
Primary source
RGD:1309287
See related
EnsemblRapid:ENSRNOG00000051440 AllianceGenome:RGD:1309287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme inhibitor activity and phosphatase regulator activity. Predicted to be involved in negative regulation of catalytic activity and signal transduction. Predicted to be located in cytoskeleton. Predicted to be active in A band and Z disc. Orthologous to human PPP1R12B (protein phosphatase 1 regulatory subunit 12B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 207.7), Muscle (RPKM 206.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ppp1r12b in Genome Data Viewer
Location:
13q13
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48751256..48948933, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46199418..46397108, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51583603..51784641, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene MGAT4 family member E Neighboring gene lysine demethylase 5B Neighboring gene synaptotagmin 2 Neighboring gene ubiquitin-conjugating enzyme E2C, pseudogene 4 Neighboring gene ubiquitin-conjugating enzyme E2T Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B. Liu K, et al. EBioMedicine, 2020 Nov. PMID 33096475, Free PMC Article
  2. Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit. Arimura T, et al. J Biol Chem, 2001 Mar 2. PMID 11067852
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
    Title: Epistatic evidence for gender-dependant slow neurotransmission signalling in substance use disorders: PPP1R12B versus PPP1R1B.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in A band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in A band ISO
Inferred from Sequence Orthology
more info
  
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 12B
Names
protein phosphatase 1, regulatory (inhibitor) subunit 12B
NP_001100648.1
XP_006249937.1
XP_006249938.1
XP_006249942.1
XP_008767780.1
XP_008767783.1
XP_017454282.1
XP_038946646.1
XP_038946647.1
XP_038946648.1
XP_063128370.1
XP_063128371.1
XP_063128373.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107178.5 → NP_001100648.1  protein phosphatase 1 regulatory subunit 12B

    See identical proteins and their annotated locations for NP_001100648.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6A534, A6ICC9, D3ZIC4
    Related
    ENSRNOP00000069748.1, ENSRNOT00000089068.3
    Conserved Domains (5) summary
    cd00204
    Location:85 → 269
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:219 → 269
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:876 → 982
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    48751256..48948933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272303.1 → XP_063128373.1  protein phosphatase 1 regulatory subunit 12B isoform X12

    UniProtKB/TrEMBL
    A0A8I6A534

  2. XM_006249876.5 → XP_006249938.1  protein phosphatase 1 regulatory subunit 12B isoform X3

    UniProtKB/TrEMBL
    A0A8I6A534, A0A8I6A6B6
    Related
    ENSRNOP00000086607.1, ENSRNOT00000107681.2
    Conserved Domains (5) summary
    cd00204
    Location:85 → 269
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:219 → 269
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:876 → 976
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]

  3. XM_008769561.4 → XP_008767783.1  protein phosphatase 1 regulatory subunit 12B isoform X11

    UniProtKB/TrEMBL
    A0A8I6GIK9
    Related
    ENSRNOP00000090864.1, ENSRNOT00000119339.2
    Conserved Domains (1) summary
    pfam15898
    Location:85 → 185
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

  4. XM_006249875.4 → XP_006249937.1  protein phosphatase 1 regulatory subunit 12B isoform X1

    UniProtKB/TrEMBL
    A0A8I6A534
    Related
    ENSRNOP00000087080.1, ENSRNOT00000100540.2
    Conserved Domains (5) summary
    cd00204
    Location:85 → 269
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:219 → 269
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:876 → 982
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]

  5. XM_039090719.2 → XP_038946647.1  protein phosphatase 1 regulatory subunit 12B isoform X4

    UniProtKB/TrEMBL
    A0A8I6A534
    Related
    ENSRNOP00000087409.2, ENSRNOT00000100428.2
    Conserved Domains (6) summary
    PHA03095
    Location:61 → 290
    PHA03095; ankyrin-like protein; Provisional
    PRK07003
    Location:530 → 702
    PRK07003; DNA polymerase III subunit gamma/tau
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:834 → 940
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cl40436
    Location:567 → 619
    IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

  6. XM_006249880.5 → XP_006249942.1  protein phosphatase 1 regulatory subunit 12B isoform X8

    See identical proteins and their annotated locations for XP_006249942.1

    UniProtKB/TrEMBL
    A0A8I6A534
    Conserved Domains (4) summary
    cd00204
    Location:47 → 133
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:51 → 101
    Ank_4; Ankyrin repeats (many copies)
    pfam15898
    Location:708 → 814
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]

  7. XM_063272301.1 → XP_063128371.1  protein phosphatase 1 regulatory subunit 12B isoform X10

  8. XM_039090718.2 → XP_038946646.1  protein phosphatase 1 regulatory subunit 12B isoform X2

    UniProtKB/TrEMBL
    A0A8I6A534
    Conserved Domains (6) summary
    PHA03095
    Location:61 → 290
    PHA03095; ankyrin-like protein; Provisional
    PHA03369
    Location:499 → 786
    PHA03369; capsid maturational protease; Provisional
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam15898
    Location:876 → 951
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cl40436
    Location:609 → 661
    IPD_PPP1R12; inhibitory phosphorylation domain of protein phosphatase 1 regulatory subunit 12 (PPP1R12) family

  9. XM_017598793.3 → XP_017454282.1  protein phosphatase 1 regulatory subunit 12B isoform X6

    UniProtKB/TrEMBL
    A0A8I6A534

  10. XM_039090720.2 → XP_038946648.1  protein phosphatase 1 regulatory subunit 12B isoform X7

    UniProtKB/TrEMBL
    A0A8I6A534
    Conserved Domains (5) summary
    PHA03095
    Location:61 → 290
    PHA03095; ankyrin-like protein; Provisional
    PHA03369
    Location:499 → 786
    PHA03369; capsid maturational protease; Provisional
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    cd21944
    Location:606 → 662
    IPD_MYPT1; inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1(MYPT1)

  11. XM_063272300.1 → XP_063128370.1  protein phosphatase 1 regulatory subunit 12B isoform X5

    UniProtKB/TrEMBL
    A0A8I6A534

  12. XM_008769558.4 → XP_008767780.1  protein phosphatase 1 regulatory subunit 12B isoform X9

    See identical proteins and their annotated locations for XP_008767780.1

    Conserved Domains (4) summary
    cd00204
    Location:85 → 269
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:65 → 154
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:219 → 269
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:90 → 121
    ANK; ANK repeat [structural motif]

RNA

  1. XR_005492243.2 RNA Sequence

  2. XR_010056917.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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