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Elf3 E74 like ETS transcription factor 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304815, updated on 2-Nov-2024

Summary

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Official Symbol
Elf3provided by RGD
Official Full Name
E74 like ETS transcription factor 3provided by RGD
Primary source
RGD:1310687
See related
EnsemblRapid:ENSRNOG00000006330 AllianceGenome:RGD:1310687
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including inflammatory response; mammary gland involution; and regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including blastocyst development; extracellular matrix organization; and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ELF3 (E74 like ETS transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 151.8), Uterus (RPKM 135.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elf3 in Genome Data Viewer
Location:
13q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49242265..49247102, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46690460..46695394, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52083873..52088798, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene ARF like GTPase 8A Neighboring gene G protein-coupled receptor 37-like 1 Neighboring gene arginyl aminopeptidase Neighboring gene translocase of inner mitochondrial membrane 17A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation. Brembeck FH, et al. Oncogene, 2000 Apr 6. PMID 10773884
  2. The epithelium-specific ets transcription factor ESX is associated with mammary gland development and involution. Neve R, et al. FASEB J, 1998 Nov. PMID 9806763
  3. Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family. Oettgen P, et al. Mol Cell Biol, 1997 Aug. PMID 9234700, Free PMC Article
  4. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. Brown C, et al. J Biol Chem, 2004 Mar 26. PMID 14715662
  5. Activation of the murine type II transforming growth factor-beta receptor gene: up-regulation and function of the transcription factor Elf-3/Ert/Esx/Ese-1. Kim JH, et al. J Biol Chem, 2002 May 17. PMID 11893733

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression.
    Title: High glucose mediates NLRP3 inflammasome activation via upregulation of ELF3 expression.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anatomical structure morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in blastocyst development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blastocyst development ISO
Inferred from Sequence Orthology
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in mammary gland involution IEA
Inferred from Electronic Annotation
more info
  
involved_in mammary gland involution ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ETS-related transcription factor Elf-3
Names
E74-like factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024768.1 → NP_001019939.1  ETS-related transcription factor Elf-3

    See identical proteins and their annotated locations for NP_001019939.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097980
    UniProtKB/Swiss-Prot
    Q4V7E1
    Related
    ENSRNOP00000108675.1, ENSRNOT00000160249.1
    Conserved Domains (2) summary
    cd08537
    Location:78 → 155
    SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
    smart00413
    Location:296 → 383
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    49242265..49247102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249883.5 → XP_006249945.1  ETS-related transcription factor Elf-3 isoform X4

    See identical proteins and their annotated locations for XP_006249945.1

    UniProtKB/TrEMBL
    A6ICE5
    Conserved Domains (2) summary
    cd08537
    Location:52 → 131
    SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
    smart00413
    Location:272 → 359
    ETS; erythroblast transformation specific domain

  2. XM_063272305.1 → XP_063128375.1  ETS-related transcription factor Elf-3 isoform X5

  3. XM_063272304.1 → XP_063128374.1  ETS-related transcription factor Elf-3 isoform X3

  4. XM_006249881.5 → XP_006249943.1  ETS-related transcription factor Elf-3 isoform X1

    UniProtKB/TrEMBL
    A0A8L2Q3H0
    Related
    ENSRNOP00000008753.5, ENSRNOT00000008754.8
    Conserved Domains (2) summary
    cd08537
    Location:77 → 154
    SAM_PNT-ESE-1-like; Sterile alpha motif (SAM)/Pointed domain of ESE-1 like ETS transcriptional regulators
    smart00413
    Location:295 → 382
    ETS; erythroblast transformation specific domain

  5. XM_017598796.3 → XP_017454285.1  ETS-related transcription factor Elf-3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V7E1.1 GenPept UniProtKB/Swiss-Prot:Q4V7E1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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