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Lmod1 leiomodin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304816, updated on 2-Nov-2024

Summary

Official Symbol
Lmod1provided by RGD
Official Full Name
leiomodin 1provided by RGD
Primary source
RGD:1307236
See related
EnsemblRapid:ENSRNOG00000051548 AllianceGenome:RGD:1307236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity and tropomyosin binding activity. Predicted to be involved in actin nucleation and positive regulation of actin filament polymerization. Located in actin filament and sarcomere. Human ortholog(s) of this gene implicated in megacystis-microcolon-intestinal hypoperistalsis syndrome. Orthologous to human LMOD1 (leiomodin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 85.8), Muscle (RPKM 76.6) and 8 other tissues See more
Orthologs
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Genomic context

See Lmod1 in Genome Data Viewer
Location:
13q13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49305693..49347970)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46754048..46796186)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52147099..52189835)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene arginyl aminopeptidase Neighboring gene translocase of inner mitochondrial membrane 17A Neighboring gene uncharacterized LOC120096253 Neighboring gene shisa family member 4 Neighboring gene importin 9

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables tropomyosin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin nucleation IEA
Inferred from Electronic Annotation
more info
 
involved_in actin nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in actin nucleation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pointed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere IDA
Inferred from Direct Assay
more info
PubMed 
located_in sarcomere IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leiomodin-1
Names
SM-Lmod
leiomodin 1 (smooth muscle)
smooth muscle leiomodin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107179.3NP_001100649.2  leiomodin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    A0A0G2K0D3
    UniProtKB/TrEMBL
    A6ICE9
    Related
    ENSRNOP00000112841.1, ENSRNOT00000154530.1
    Conserved Domains (3) summary
    PTZ00121
    Location:73326
    PTZ00121; MAEBL; Provisional
    pfam03250
    Location:1395
    Tropomodulin
    cl39015
    Location:315446
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. NM_001430078.1NP_001417007.1  leiomodin-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8L2R3Z2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    49305693..49347970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272307.1XP_063128377.1  leiomodin-1 isoform X1

    Related
    ENSRNOP00000071399.2, ENSRNOT00000084766.3