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Tor1aip2 torsin 1A interacting protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304881, updated on 2-Nov-2024

Summary

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Official Symbol
Tor1aip2provided by RGD
Official Full Name
torsin 1A interacting protein 2provided by RGD
Primary source
RGD:735059
See related
EnsemblRapid:ENSRNOG00000024849 EnsemblRapid:ENSRNOG00000048267 AllianceGenome:RGD:735059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATPase activator activity and ATPase binding activity. Predicted to be involved in several processes, including endoplasmic reticulum organization; positive regulation of ATP-dependent activity; and protein localization to nuclear envelope. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in endoplasmic reticulum and membrane. Orthologous to human TOR1AIP2 (torsin 1A interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 206.9), Liver (RPKM 192.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tor1aip2 in Genome Data Viewer
Location:
13q22
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (70775483..70806794)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (68225226..68256536)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (73704088..73735339)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096287 Neighboring gene centrosomal protein 350 Neighboring gene interferon induced transmembrane protein 2, pseudogene 2 Neighboring gene torsin 1A interacting protein 1 Neighboring gene family with sequence similarity 163, member A Neighboring gene uncharacterized LOC120096289 Neighboring gene ATP synthase F1 subunit gamma, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation. Vander Heyden AB, et al. Mol Biol Cell, 2009 Jun. PMID 19339278, Free PMC Article
  2. Arresting a Torsin ATPase reshapes the endoplasmic reticulum. Rose AE, et al. J Biol Chem, 2014 Jan 3. PMID 24275647, Free PMC Article
  3. The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein. Goodchild RE, et al. J Cell Biol, 2005 Mar 14. PMID 15767459, Free PMC Article
  4. Regulation of Torsin ATPases by LAP1 and LULL1. Zhao C, et al. Proc Natl Acad Sci U S A, 2013 Apr 23. PMID 23569223, Free PMC Article
  5. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC72610

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables ATPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATP-dependent activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
torsin-1A-interacting protein 2; interferon alpha responsive protein
Names
torsin A interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165896.1 → NP_001159368.1  interferon alpha responsive protein isoform a

    See identical proteins and their annotated locations for NP_001159368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) shares a portion of its 5' UTR, but no coding sequence with variant 1. Variant 2 encodes a shorter protein (interferon alpha responsive protein), which is distinct from torsin-1A-interacting protein 2. Variants 2 and 3 encode the same protein, isoform a.
    Source sequence(s)
    CB804669, CO565924, CV107022, DV728294, EV767100
    UniProtKB/TrEMBL
    M0R5U6
    Related
    ENSRNOP00000071656.1, ENSRNOT00000077874.3

  2. NM_001165897.1 → NP_001159369.1  interferon alpha responsive protein isoform a

    See identical proteins and their annotated locations for NP_001159369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) shares a portion of its 5' UTR, but no coding sequence with variant 1. Variant 3 encodes a shorter protein, (interferon alpha responsive protein), which is distinct from torsin-1A-interacting protein 2. Variants 2 and 3 encode the same protein, isoform a.
    Source sequence(s)
    CB804669, CK478392, CO565924, DV728294, EV767100
    UniProtKB/TrEMBL
    M0R5U6
    Related
    ENSRNOP00000084434.1, ENSRNOT00000104928.2

  3. NM_199100.4 → NP_954531.1  torsin-1A-interacting protein 2 isoform b

    See identical proteins and their annotated locations for NP_954531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein, isoform b, referred to as torsin-1A-interacting protein 2.
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    Q6P752
    UniProtKB/TrEMBL
    A0A8I6AJQ9
    Conserved Domains (1) summary
    pfam05609
    Location:28 → 568
    LAP1C; Lamina-associated polypeptide 1C (LAP1C)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    70775483..70806794
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250045.5 → XP_006250107.1  torsin-1A-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006250107.1

    UniProtKB/Swiss-Prot
    Q6P752
    UniProtKB/TrEMBL
    A0A8I6AJQ9
    Conserved Domains (1) summary
    pfam05609
    Location:28 → 568
    LAP1C; Lamina-associated polypeptide 1C (LAP1C)

  2. XM_039090736.2 → XP_038946664.1  torsin-1A-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P752
    UniProtKB/TrEMBL
    A0A8I6AJQ9
    Conserved Domains (1) summary
    pfam05609
    Location:28 → 568
    LAP1C; Lamina-associated polypeptide 1C (LAP1C)

  3. XM_039090735.2 → XP_038946663.1  torsin-1A-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q6P752
    UniProtKB/TrEMBL
    A0A8I6AJQ9
    Related
    ENSRNOP00000039176.3, ENSRNOT00000050734.6
    Conserved Domains (1) summary
    pfam05609
    Location:28 → 568
    LAP1C; Lamina-associated polypeptide 1C (LAP1C)

  4. XM_006250043.5 → XP_006250105.1  torsin-1A-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006250105.1

    UniProtKB/Swiss-Prot
    Q6P752
    UniProtKB/TrEMBL
    A0A8I6AJQ9
    Conserved Domains (1) summary
    pfam05609
    Location:28 → 568
    LAP1C; Lamina-associated polypeptide 1C (LAP1C)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P752.1 GenPept UniProtKB/Swiss-Prot:Q6P752

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