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Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304887, updated on 2-Nov-2024

Summary

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Official Symbol
Ralgps2provided by RGD
Official Full Name
Ral GEF with PH domain and SH3 binding motif 2provided by RGD
Primary source
RGD:1311537
See related
EnsemblRapid:ENSRNOG00000004736 AllianceGenome:RGD:1311537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RALGPS2 (Ral GEF with PH domain and SH3 binding motif 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 753.7), Spleen (RPKM 285.0) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ralgps2 in Genome Data Viewer
Location:
13q22
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (71474835..71654791, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (68924674..69104637, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (74446001..74520640, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481575 Neighboring gene enolase 1 like 2 Neighboring gene angiopoietin-like 1 Neighboring gene C-type lectin domain containing 20A Neighboring gene testis expressed 35 Neighboring gene RAS protein activator like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The PH-PxxP domain of RalGPS2 promotes PC12 cells differentiation acting as a dominant negative for RalA GTPase activation. Ceriani M, et al. Neurosci Res, 2010 Mar. PMID 20025911
  2. Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. Rebhun JF, et al. J Biol Chem, 2000 May 5. PMID 10747847
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-specific guanine nucleotide-releasing factor RalGPS2
Names
Ral-A exchange factor RalGPS2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100680.1 → NP_001094150.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform 2

    See identical proteins and their annotated locations for NP_001094150.1

    Status: VALIDATED

    Source sequence(s)
    BC105626
    UniProtKB/TrEMBL
    A6ID21, F1MAR5, Q0VGK1
    Conserved Domains (1) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  2. NM_001401396.1 → NP_001388325.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6GHG1
    Related
    ENSRNOP00000089573.1, ENSRNOT00000103744.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    71474835..71654791 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090756.2 → XP_038946684.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTI5, A0A8I6GHG1
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:459 → 574
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  2. XM_063272338.1 → XP_063128408.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XSQ7

  3. XM_039090753.2 → XP_038946681.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTI5, A0A8I6GHG1
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:459 → 574
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  4. XM_039090758.2 → XP_038946686.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JTI5, A0A8J8XSQ7
    Related
    ENSRNOP00000033737.5, ENSRNOT00000036200.6
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:433 → 548
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  5. XM_063272340.1 → XP_063128410.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XSQ7

  6. XM_039090755.2 → XP_038946683.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTI5, A0A8I6GHG1
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:459 → 574
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  7. XM_063272339.1 → XP_063128409.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XSQ7

  8. XM_039090752.2 → XP_038946680.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTI5, A0A8I6GHG1
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:459 → 574
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  9. XM_063272335.1 → XP_063128405.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GHG1
    Related
    ENSRNOP00000089846.1, ENSRNOT00000116366.2

  10. XM_063272336.1 → XP_063128406.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XSQ7

  11. XM_063272341.1 → XP_063128411.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X2

    UniProtKB/TrEMBL
    A0A8J8XSQ7

  12. XM_063272334.1 → XP_063128404.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GHG1

  13. XM_039090757.2 → XP_038946685.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTI5, A0A8I6GHG1
    Conserved Domains (2) summary
    smart00147
    Location:45 → 286
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    cd13310
    Location:459 → 574
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain

  14. XM_063272333.1 → XP_063128403.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GHG1

  15. XM_039090761.2 → XP_038946689.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A8Z1
    Conserved Domains (2) summary
    cd13310
    Location:319 → 434
    PH_RalGPS1_2; Ral GEF with PH domain and SH3 binding motif 1 and 2 Pleckstrin homology (PH) domain
    cl02485
    Location:1 → 146
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  16. XM_063272342.1 → XP_063128412.1  ras-specific guanine nucleotide-releasing factor RalGPS2 isoform X4

Nucleotide Protein Strain
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