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Tbx19 T-box transcription factor 19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304935, updated on 17-Aug-2024

Summary

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Official Symbol
Tbx19provided by RGD
Official Full Name
T-box transcription factor 19provided by RGD
Primary source
RGD:1310145
See related
EnsemblRapid:ENSRNOG00000002979 AllianceGenome:RGD:1310145
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including cell fate specification; mesoderm formation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cell fate commitment; pituitary gland development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in adrenocorticotropic hormone deficiency and inherited metabolic disorder. Orthologous to human TBX19 (T-box transcription factor 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 16.5), Lung (RPKM 8.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tbx19 in Genome Data Viewer
Location:
13q23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (79983935..80016219, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (77450848..77484475, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83403263..83426305, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481586 Neighboring gene uncharacterized LOC120096303 Neighboring gene SFT2 domain containing 2 Neighboring gene TOR signaling pathway regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins. Lamolet B, et al. Cell, 2001 Mar 23. PMID 11290323
  2. Tbx19, a tissue-selective regulator of POMC gene expression. Liu J, et al. Proc Natl Acad Sci U S A, 2001 Jul 17. PMID 11447259, Free PMC Article
  3. Tpit determines alternate fates during pituitary cell differentiation. Pulichino AM, et al. Genes Dev, 2003 Mar 15. PMID 12651892, Free PMC Article
  4. The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Budry L, et al. Genes Dev, 2012 Oct 15. PMID 23070814, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell fate commitment ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pituitary gland development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-box transcription factor TBX19
Names
T-box 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394230.1 → NP_001381159.1  T-box transcription factor TBX19

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6AH75, A0A8I6AWA6
    Related
    ENSRNOP00000062131.2, ENSRNOT00000063870.3
    Conserved Domains (1) summary
    cd20201
    Location:36 → 218
    T-box_TBX19-like; DNA-binding domain of T-box transcription factor 19 and related T-box proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    79983935..80016219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090785.2 → XP_038946713.1  T-box transcription factor TBX19 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AH75, A0A8I6AWA6
    Conserved Domains (1) summary
    cd20201
    Location:36 → 218
    T-box_TBX19-like; DNA-binding domain of T-box transcription factor 19 and related T-box proteins

  2. XM_039090786.2 → XP_038946714.1  T-box transcription factor TBX19 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AH75, A0A8I6AWA6
    Conserved Domains (1) summary
    cd20201
    Location:36 → 218
    T-box_TBX19-like; DNA-binding domain of T-box transcription factor 19 and related T-box proteins

  3. XM_063272363.1 → XP_063128433.1  T-box transcription factor TBX19 isoform X2

  4. XM_063272362.1 → XP_063128432.1  T-box transcription factor TBX19 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107193.1: Suppressed sequence

    Description
    NM_001107193.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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