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Sdccag8 SHH signaling and ciliogenesis regulator SDCCAG8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305002, updated on 10-Oct-2024

Summary

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Official Symbol
Sdccag8provided by RGD
Official Full Name
SHH signaling and ciliogenesis regulator SDCCAG8provided by RGD
Primary source
RGD:727781
See related
EnsemblRapid:ENSRNOG00000004181 AllianceGenome:RGD:727781
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in several processes, including microtubule organizing center organization; neuron migration; and regulation of cilium assembly. Predicted to be located in several cellular components, including cell-cell junction; microtubule organizing center; and photoreceptor cell cilium. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 16 and Senior-Loken syndrome. Orthologous to human SDCCAG8 (SHH signaling and ciliogenesis regulator SDCCAG8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 47.7), Thymus (RPKM 29.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sdccag8 in Genome Data Viewer
Location:
13q24-q25
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (91286787..91518255)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (88754521..88979363)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (94888046..95100833)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene phospholipase D family, member 5 Neighboring gene centrosomal protein 170 Neighboring gene microRNA 350 Neighboring gene uncharacterized LOC134481601 Neighboring gene AKT serine/threonine kinase 3 Neighboring gene uncharacterized LOC134481600

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of the centrosomal colon cancer autoantigen gene during spermatogenesis in the maturing rat testis. Kamio T, et al. Biosci Biotechnol Biochem, 2010. PMID 20622438
  2. Identification and characterization of the novel centrosome-associated protein CCCAP. Kenedy AA, et al. Gene, 2003 Jan 16. PMID 12559564
  3. Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Otto EA, et al. Nat Genet, 2010 Oct. PMID 20835237, Free PMC Article
  4. SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling. Airik R, et al. PLoS One, 2016. PMID 27224062, Free PMC Article
  5. SDCCAG8 regulates pericentriolar material recruitment and neuronal migration in the developing cortex. Insolera R, et al. Neuron, 2014 Aug 20. PMID 25088364, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the gene and protein expression of serologically defined colon cancer antigen 8
    Title: Expression of the centrosomal colon cancer autoantigen gene during spermatogenesis in the maturing rat testis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC93052

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in centrosome cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule organizing center organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule organizing center organization ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in tube formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tube formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in photoreceptor cell cilium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serologically defined colon cancer antigen 8
Names
serologically defined colon cancer antigen 8 homolog
slinky

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177929.3 → NP_808790.2  serologically defined colon cancer antigen 8

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    F6SRB4, Q5PQY1, Q812C8
    Related
    ENSRNOP00000098292.2, ENSRNOT00000120659.2
    Conserved Domains (1) summary
    pfam15964
    Location:6 → 709
    CCCAP; Centrosomal colon cancer autoantigen protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    91286787..91518255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090807.2 → XP_038946735.1  serologically defined colon cancer antigen 8 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JZ58, A0A8I6A6Q1
    Related
    ENSRNOP00000098293.2, ENSRNOT00000120660.2
    Conserved Domains (1) summary
    pfam15964
    Location:6 → 708
    CCCAP; Centrosomal colon cancer autoantigen protein family

  2. XM_063272378.1 → XP_063128448.1  serologically defined colon cancer antigen 8 isoform X5

  3. XM_039090810.2 → XP_038946738.1  serologically defined colon cancer antigen 8 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JZ58
    Conserved Domains (1) summary
    pfam15964
    Location:6 → 628
    CCCAP; Centrosomal colon cancer autoantigen protein family

  4. XM_006250321.5 → XP_006250383.1  serologically defined colon cancer antigen 8 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JZ58, A0A8I5ZYP1
    Related
    ENSRNOP00000098296.2, ENSRNOT00000120663.2
    Conserved Domains (1) summary
    pfam15964
    Location:6 → 707
    CCCAP; Centrosomal colon cancer autoantigen protein family

  5. XM_006250322.5 → XP_006250384.1  serologically defined colon cancer antigen 8 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JUD0, A0A0G2JZ58
    Related
    ENSRNOP00000069051.2, ENSRNOT00000077995.4
    Conserved Domains (1) summary
    pfam15964
    Location:6 → 707
    CCCAP; Centrosomal colon cancer autoantigen protein family

  6. XM_063272381.1 → XP_063128451.1  serologically defined colon cancer antigen 8 isoform X11

  7. XM_063272380.1 → XP_063128450.1  serologically defined colon cancer antigen 8 isoform X9

    Related
    ENSRNOP00000098289.2, ENSRNOT00000120656.2

  8. XM_039090812.2 → XP_038946740.2  serologically defined colon cancer antigen 8 isoform X12

  9. XM_063272377.1 → XP_063128447.1  serologically defined colon cancer antigen 8 isoform X1

  10. XM_063272379.1 → XP_063128449.1  serologically defined colon cancer antigen 8 isoform X8

  11. XM_063272383.1 → XP_063128453.1  serologically defined colon cancer antigen 8 isoform X12

  12. XM_008769789.4 → XP_008768011.1  serologically defined colon cancer antigen 8 isoform X6

    UniProtKB/TrEMBL
    A0A8I6A2X0
    Conserved Domains (1) summary
    pfam15964
    Location:6 → 666
    CCCAP; Centrosomal colon cancer autoantigen protein family

  13. XM_039090808.2 → XP_038946736.1  serologically defined colon cancer antigen 8 isoform X7

    UniProtKB/TrEMBL
    A0A8I6A2X0
    Conserved Domains (1) summary
    pfam15964
    Location:6 → 665
    CCCAP; Centrosomal colon cancer autoantigen protein family

  14. XM_039090814.2 → XP_038946742.1  serologically defined colon cancer antigen 8 isoform X14

    UniProtKB/TrEMBL
    A0A8I6A2X0
    Conserved Domains (1) summary
    pfam15964
    Location:6 → 543
    CCCAP; Centrosomal colon cancer autoantigen protein family

  15. XM_063272384.1 → XP_063128454.1  serologically defined colon cancer antigen 8 isoform X13

  16. XM_039090811.2 → XP_038946739.2  serologically defined colon cancer antigen 8 isoform X12

  17. XM_063272382.1 → XP_063128452.1  serologically defined colon cancer antigen 8 isoform X12

  18. XM_063272385.1 → XP_063128455.1  serologically defined colon cancer antigen 8 isoform X15

RNA

  1. XR_010056919.1 RNA Sequence

  2. XR_010056920.1 RNA Sequence

  3. XR_005492248.2 RNA Sequence

  4. XR_005492249.2 RNA Sequence

  5. XR_005492250.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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