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Tp53bp2 tumor protein p53 binding protein, 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305025, updated on 18-Sep-2024

Summary

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Official Symbol
Tp53bp2provided by RGD
Official Full Name
tumor protein p53 binding protein, 2provided by RGD
Primary source
RGD:1305461
See related
EnsemblRapid:ENSRNOG00000003237 AllianceGenome:RGD:1305461
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Trp53bp2
Summary
Predicted to enable NF-kappaB binding activity; identical protein binding activity; and p53 binding activity. Involved in positive regulation of neuron death. Located in nucleus. Orthologous to human TP53BP2 (tumor protein p53 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 126.8), Thymus (RPKM 74.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tp53bp2 in Genome Data Viewer
Location:
13q26
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (96620429..96677090)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (94088769..94145436)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (100817206..100873837)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352584 Neighboring gene delta(4)-desaturase, sphingolipid 1 Neighboring gene F-box protein 28 Neighboring gene uncharacterized LOC102555308 Neighboring gene calpain 2 Neighboring gene uncharacterized LOC120096330

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The DEAD box protein Ddx42p modulates the function of ASPP2, a stimulator of apoptosis. Uhlmann-Schiffler H, et al. Oncogene, 2009 May 21. PMID 19377511
  2. ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Vives V, et al. Genes Dev, 2006 May 15. PMID 16702401, Free PMC Article
  3. APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. Nakagawa H, et al. Cancer Res, 2000 Jan 1. PMID 10646860
  4. The structure and interactions of the proline-rich domain of ASPP2. Rotem S, et al. J Biol Chem, 2008 Jul 4. PMID 18448430
  5. Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. Cao Y, et al. Biochem Biophys Res Commun, 2004 Mar 19. PMID 14985081

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within central nervous system development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryo development ending in birth or egg hatching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
apoptosis-stimulating of p53 protein 2
Names
transformation related protein 53 binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427417.1 → NP_001414346.1  apoptosis-stimulating of p53 protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6ANU5, A6JGL8, F1M5H6
    Related
    ENSRNOP00000004330.6, ENSRNOT00000004330.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    96620429..96677090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091490.2 → XP_038947418.1  apoptosis-stimulating of p53 protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ANU5, A6JGL8
    Conserved Domains (6) summary
    PHA03247
    Location:332 → 731
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:128 → 330
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:914 → 940
    ANK; ANK repeat [structural motif]
    cd17225
    Location:10 → 89
    RA_ASPP2; Ras-associating (RA) domain found in apoptosis-stimulating protein of p53 protein 2 (ASPP2)
    pfam12796
    Location:914 → 1000
    Ank_2; Ankyrin repeats (3 copies)
    cl17036
    Location:1044 → 1100
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version

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