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Pacc1 proton activated chloride channel 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305070, updated on 17-Aug-2024

Summary

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Official Symbol
Pacc1provided by RGD
Official Full Name
proton activated chloride channel 1provided by RGD
Primary source
RGD:1359339
See related
EnsemblRapid:ENSRNOG00000003915 AllianceGenome:RGD:1359339
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PAC; Tmem206; RGD1359339
Summary
Predicted to enable pH-gated chloride channel activity. Predicted to be involved in chloride transport. Predicted to act upstream of or within anion transmembrane transport and inorganic anion transport. Predicted to be integral component of plasma membrane. Predicted to be part of chloride channel complex. Orthologous to human PACC1 (proton activated chloride channel 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 138.6), Spleen (RPKM 88.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q27
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105435772..105460877)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (102904668..102929770)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (110006975..110032790)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555043 Neighboring gene uncharacterized LOC102555129 Neighboring gene uncharacterized LOC134481545 Neighboring gene neudesin neurotrophic factor Neighboring gene protein phosphatase 2, regulatory subunit B', alpha Neighboring gene uncharacterized LOC120096352

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. Ullrich F, et al. Elife, 2019 Jul 18. PMID 31318332, Free PMC Article
  2. PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel. Yang J, et al. Science, 2019 Apr 26. PMID 31023925, Free PMC Article
  3. Quantitative proteomics identifies a Dab2/integrin module regulating cell migration. Teckchandani A, et al. J Cell Biol, 2009 Jul 13. PMID 19581412, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC95217

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables pH-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables pH-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables pH-gated chloride channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transport ISO
Inferred from Sequence Orthology
more info
  
involved_in chloride transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proton-activated chloride channel
Names
transmembrane protein 206

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007679.1 → NP_001007680.1  proton-activated chloride channel

    See identical proteins and their annotated locations for NP_001007680.1

    Status: PROVISIONAL

    Source sequence(s)
    BC082061
    UniProtKB/Swiss-Prot
    Q66H28
    UniProtKB/TrEMBL
    A0A8I5ZNJ7, A6JGZ6
    Related
    ENSRNOP00000005387.4, ENSRNOT00000005387.8
    Conserved Domains (1) summary
    pfam15122
    Location:55 → 349
    TMEM206; TMEM206 protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    105435772..105460877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250481.5 → XP_006250543.1  proton-activated chloride channel isoform X1

    Conserved Domains (1) summary
    pfam15122
    Location:44 → 279
    TMEM206; TMEM206 protein family

  2. XM_063272397.1 → XP_063128467.1  proton-activated chloride channel isoform X2

RNA

  1. XR_010056921.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H28.1 GenPept UniProtKB/Swiss-Prot:Q66H28

Gene LinkOut

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