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Dtl denticleless E3 ubiquitin protein ligase homolog [ Rattus norvegicus (Norway rat) ]

Gene ID: 305073, updated on 28-Oct-2024

Summary

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Symbol
Dtlprovided by RGD
Full Name
denticleless E3 ubiquitin protein ligase homologprovided by RGD
Primary source
RGD:1310439
See related
EnsemblRapid:ENSRNOG00000004195 AllianceGenome:RGD:1310439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310439
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Predicted to be located in centrosome; cytosol; and nuclear lumen. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human DTL (denticleless E3 ubiquitin protein ligase homolog). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 61.0), Spleen (RPKM 44.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dtl in Genome Data Viewer
Location:
13q27
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (105646908..105685921, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (103115810..103155029, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (110219276..110257345, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096352 Neighboring gene stratifin, pseudogene 1 Neighboring gene integrator complex subunit 7 Neighboring gene ribosomal protein L12, pseudogene 10 Neighboring gene ribosomal protein S18, pseudogene 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Role of L2DTL, cell cycle-regulated nuclear and centrosome protein, in aggressive hepatocellular carcinoma. Pan HW, et al. Cell Cycle, 2006 Nov. PMID 17106265
  2. DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Sansam CL, et al. Genes Dev, 2006 Nov 15. PMID 17085480, Free PMC Article
  3. CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1. Tong X, et al. PLoS One, 2015. PMID 26431207, Free PMC Article
  4. CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis. Terai K, et al. Mol Cell, 2010 Jan 15. PMID 20129063, Free PMC Article
  5. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Abbas T, et al. Genes Dev, 2008 Sep 15. PMID 18794347, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV ISO
Inferred from Sequence Orthology
more info
  
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
  
involved_in translesion synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4B-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
denticleless protein homolog
Names
denticleless homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427431.1 → NP_001414360.1  denticleless protein homolog

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    Related
    ENSRNOP00000005576.6, ENSRNOT00000005576.9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    105646908..105685921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091506.2 → XP_038947434.1  denticleless protein homolog isoform X1

    UniProtKB/TrEMBL
    A6JGZ8
    Conserved Domains (2) summary
    sd00039
    Location:40 → 76
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:3 → 327
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_039091504.2 → XP_038947432.1  denticleless protein homolog isoform X1

    UniProtKB/TrEMBL
    A6JGZ8
    Conserved Domains (2) summary
    sd00039
    Location:40 → 76
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:3 → 327
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_063272400.1 → XP_063128470.1  denticleless protein homolog isoform X1

  4. XM_063272399.1 → XP_063128469.1  denticleless protein homolog isoform X1

    Related
    ENSRNOP00000083831.2, ENSRNOT00000095446.2

  5. XM_063272398.1 → XP_063128468.1  denticleless protein homolog isoform X1

  6. XM_017599014.3 → XP_017454503.1  denticleless protein homolog isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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