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Arhgap24 Rho GTPase activating protein 24 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305156, updated on 2-Nov-2024

Summary

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Official Symbol
Arhgap24provided by RGD
Official Full Name
Rho GTPase activating protein 24provided by RGD
Primary source
RGD:1306669
See related
EnsemblRapid:ENSRNOG00000056944 AllianceGenome:RGD:1306669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DR-NR#2
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of Rac protein signal transduction; negative regulation of ruffle assembly; and wound healing, spreading of epidermal cells. Predicted to act upstream of or within activation of GTPase activity. Predicted to be located in several cellular components, including adherens junction; cell projection; and cytoskeleton. Predicted to be active in focal adhesion. Orthologous to human ARHGAP24 (Rho GTPase activating protein 24). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 258.2), Lung (RPKM 31.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgap24 in Genome Data Viewer
Location:
14p22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (7105200..7488437, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (6800624..7183877, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (8383211..8600526, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene mitogen activated protein kinase 10 Neighboring gene cytochrome c oxidase assembly protein COX20, mitochondrial-like Neighboring gene peptidyl-prolyl cis-trans isomerase FKBP2-like Neighboring gene uncharacterized LOC134481822 Neighboring gene uncharacterized LOC134481821 Neighboring gene uncharacterized LOC102549277 Neighboring gene uncharacterized LOC134481823

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes. Saito K, et al. FASEB J, 2024 Mar 15. PMID 38421271
  2. Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. Akilesh S, et al. J Clin Invest, 2011 Oct. PMID 21911940, Free PMC Article
  3. Gene expression variance based on random sequencing in rat remnant kidney. Horiba N, et al. Kidney Int, 2004 Jul. PMID 15200410
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes.
    Title: FilGAP controls cell-extracellular matrix adhesion and process formation of kidney podocytes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Rac protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in wound healing, spreading of epidermal cells IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within wound healing, spreading of epidermal cells ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 24
Names
Down-regulated in nephrectomized rat kidney #2
rho-type GTPase-activating protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012032.2 → NP_001012032.2  rho GTPase-activating protein 24 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0U1RRQ9, A0A0X1KG81
    Related
    ENSRNOP00000075613.2, ENSRNOT00000089800.4
    Conserved Domains (2) summary
    COG1196
    Location:558 → 644
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd04390
    Location:39 → 237
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...

  2. NM_001393820.1 → NP_001380749.1  rho GTPase-activating protein 24 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q5U2Z7, Q6I7R2
    UniProtKB/TrEMBL
    A0A0U1RRQ9, A6K5V9
    Related
    ENSRNOP00000072212.2, ENSRNOT00000080758.4
    Conserved Domains (3) summary
    COG1196
    Location:649 → 735
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd04390
    Location:130 → 328
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    cd13379
    Location:17 → 130
    PH_RhoGap24; Rho GTPase activating protein 24 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    7105200..7488437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091823.2 → XP_038947751.1  rho GTPase-activating protein 24 isoform X1

    Related
    ENSRNOP00000099081.1, ENSRNOT00000141948.1
    Conserved Domains (3) summary
    COG1196
    Location:686 → 772
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd04390
    Location:167 → 365
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    cd13379
    Location:54 → 167
    PH_RhoGap24; Rho GTPase activating protein 24 Pleckstrin homology (PH) domain

  2. XM_063273047.1 → XP_063129117.1  rho GTPase-activating protein 24 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K2E5, A6K5W0

  3. XM_006250652.5 → XP_006250714.1  rho GTPase-activating protein 24 isoform X3

    See identical proteins and their annotated locations for XP_006250714.1

    UniProtKB/TrEMBL
    A0A0G2K2E5, A0A0U1RRQ9, A6K5W0
    Conserved Domains (4) summary
    cd04390
    Location:36 → 234
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:4 → 29
    PH; PH domain
    pfam15035
    Location:567 → 644
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl17171
    Location:1 → 36
    PH-like; Pleckstrin homology-like domain

  4. XM_017599166.3 → XP_017454655.1  rho GTPase-activating protein 24 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K2E5, A0A0U1RRQ9, A6K5W0
    Conserved Domains (4) summary
    cd04390
    Location:36 → 234
    RhoGAP_ARHGAP22_24_25; RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been ...
    pfam00169
    Location:4 → 29
    PH; PH domain
    pfam15035
    Location:567 → 644
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl17171
    Location:1 → 36
    PH-like; Pleckstrin homology-like domain

  5. XM_063273046.1 → XP_063129116.1  rho GTPase-activating protein 24 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2Z7.2 GenPept UniProtKB/Swiss-Prot:Q5U2Z7

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