U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prdm8 PR/SET domain 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305198, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Prdm8provided by RGD
Official Full Name
PR/SET domain 8provided by RGD
Primary source
RGD:1311628
See related
EnsemblRapid:ENSRNOG00000002004 AllianceGenome:RGD:1311628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable chromatin binding activity; histone H3K9 methyltransferase activity; and transcription corepressor activity. Predicted to be involved in oligodendrocyte development and regulation of DNA-templated transcription. Predicted to act upstream of or within corpus callosum morphogenesis; corticospinal tract morphogenesis; and negative regulation of DNA-templated transcription. Predicted to be located in nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 10. Orthologous to human PRDM8 (PR/SET domain 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 19.1), Muscle (RPKM 11.8) and 4 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Prdm8 in Genome Data Viewer
Location:
14p22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (11708477..11728111, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (11403202..11424059, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (13052776..13073583, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 299 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene fibroblast growth factor 5 Neighboring gene ANTXR cell adhesion molecule 2 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Histone methyltransferase PRDM8 regulates mouse testis steroidogenesis. Eom GH, et al. Biochem Biophys Res Commun, 2009 Oct 9. PMID 19646955
  2. Early-onset Lafora body disease. Turnbull J, et al. Brain, 2012 Sep. PMID 22961547, Free PMC Article
  3. Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly. Ross SE, et al. Neuron, 2012 Jan 26. PMID 22284184, Free PMC Article
  4. Prdm proto-oncogene transcription factor family expression and interaction with the Notch-Hes pathway in mouse neurogenesis. Kinameri E, et al. PLoS One, 2008. PMID 19050759, Free PMC Article
  5. Histone lysine methylation dynamics: establishment, regulation, and biological impact. Black JC, et al. Mol Cell, 2012 Nov 30. PMID 23200123, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H3K9 methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within central nervous system projection neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within corpus callosum morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within corticospinal tract morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neurogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in oligodendrocyte development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
PR domain zinc finger protein 8
Names
PR domain 8
PR domain containing 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001371967.1 → NP_001358896.1  PR domain zinc finger protein 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    D4A123
    Related
    ENSRNOP00000002746.4, ENSRNOT00000002746.8
    Conserved Domains (3) summary
    sd00017
    Location:627 → 647
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:667 → 688
    zf-C2H2; Zinc finger, C2H2 type
    cd19192
    Location:6 → 138
    PR-SET_PRDM8; PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    11708477..11728111 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599430.3 → XP_017454919.1  PR domain zinc finger protein 8 isoform X1

    Conserved Domains (3) summary
    sd00017
    Location:628 → 648
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:668 → 689
    zf-C2H2; Zinc finger, C2H2 type
    pfam00856
    Location:29 → 131
    SET; SET domain

  2. XM_063273053.1 → XP_063129123.1  PR domain zinc finger protein 8 isoform X1

    Related
    ENSRNOP00000099430.1, ENSRNOT00000173510.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107207.1: Suppressed sequence

    Description
    NM_001107207.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PRDM8 (GeneID:56978).
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools