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Paqr3 progestin and adipoQ receptor family member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305203, updated on 2-Nov-2024

Summary

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Official Symbol
Paqr3provided by RGD
Official Full Name
progestin and adipoQ receptor family member 3provided by RGD
Primary source
RGD:1310426
See related
EnsemblRapid:ENSRNOG00000002035 AllianceGenome:RGD:1310426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signaling receptor activity. Predicted to act upstream of or within negative regulation of neuron projection development; negative regulation of protein phosphorylation; and protein localization to Golgi apparatus. Predicted to be located in Golgi apparatus. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 60.8), Spleen (RPKM 54.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Paqr3 in Genome Data Viewer
Location:
14p22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (12766539..12796461)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (12462568..12484999)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (14107513..14129780)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S19 like 5 Neighboring gene U6 spliceosomal RNA Neighboring gene BMP-2 inducible kinase Neighboring gene uncharacterized LOC134481718 Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exosomes from linc00511-overexpressing ADSCs accelerates angiogenesis in diabetic foot ulcers healing by suppressing PAQR3-induced Twist1 degradation. Qiu J, et al. Diabetes Res Clin Pract, 2021 Oct. PMID 34461141
  2. Spatial regulation of Raf kinase signaling by RKTG. Feng L, et al. Proc Natl Acad Sci U S A, 2007 Sep 4. PMID 17724343, Free PMC Article
  3. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang YT, et al. J Mol Evol, 2005 Sep. PMID 16044242
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomes from linc00511-overexpressing ADSCs accelerates angiogenesis in diabetic foot ulcers healing by suppressing PAQR3-induced Twist1 degradation.
    Title: Exosomes from linc00511-overexpressing ADSCs accelerates angiogenesis in diabetic foot ulcers healing by suppressing PAQR3-induced Twist1 degradation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
progestin and adipoQ receptor family member 3
Names
progestin and adipoQ receptor family member III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012033.2 → NP_001012033.1  progestin and adipoQ receptor family member 3

    See identical proteins and their annotated locations for NP_001012033.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6K658, A6K659, F7ELC3, Q6AXP7
    Conserved Domains (1) summary
    pfam03006
    Location:64 → 283
    HlyIII; Haemolysin-III related

  2. NM_001428777.1 → NP_001415706.1  progestin and adipoQ receptor family member 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6K658, F7ELC3, Q6AXP7

  3. NM_001428779.1 → NP_001415708.1  progestin and adipoQ receptor family member 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6K658, F7ELC3, Q6AXP7

  4. NM_001428781.1 → NP_001415710.1  progestin and adipoQ receptor family member 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6K658, F7ELC3, Q6AXP7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    12766539..12796461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599171.3 → XP_017454660.1  progestin and adipoQ receptor family member 3 isoform X1

    Related
    ENSRNOP00000037290.4, ENSRNOT00000032130.6
    Conserved Domains (1) summary
    pfam03006
    Location:64 → 283
    HlyIII; Haemolysin-III related

  2. XM_017599170.3 → XP_017454659.1  progestin and adipoQ receptor family member 3 isoform X1

    Conserved Domains (1) summary
    pfam03006
    Location:64 → 283
    HlyIII; Haemolysin-III related

  3. XM_039091840.2 → XP_038947768.1  progestin and adipoQ receptor family member 3 isoform X2

    Conserved Domains (1) summary
    cl03831
    Location:4 → 193
    HlyIII; Haemolysin-III related

  4. XM_039091841.2 → XP_038947769.1  progestin and adipoQ receptor family member 3 isoform X2

    Conserved Domains (1) summary
    cl03831
    Location:4 → 193
    HlyIII; Haemolysin-III related

RNA

  1. XR_010057364.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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