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Septin11 septin 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305227, updated on 17-Aug-2024

Summary

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Official Symbol
Septin11provided by RGD
Official Full Name
septin 11provided by RGD
Primary source
RGD:1307405
See related
EnsemblRapid:ENSRNOG00000002182 AllianceGenome:RGD:1307405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sept11
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Involved in regulation of synapse organization. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization of symmetric synapse. Orthologous to human SEPTIN11 (septin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 177.5), Brain (RPKM 165.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (15119760..15275222, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (14844759..14990856, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (16369544..16405645, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3, pseudogene 2 Neighboring gene cyclin G2 Neighboring gene cyclin I Neighboring gene uncharacterized LOC134481828 Neighboring gene uncharacterized LOC134481721 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene sosondowah ankyrin repeat domain family member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Septin 11 is present in GABAergic synapses and plays a functional role in the cytoarchitecture of neurons and GABAergic synaptic connectivity. Li X, et al. J Biol Chem, 2009 Jun 19. PMID 19380581, Free PMC Article
  2. Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11. Nagata K, et al. J Biol Chem, 2004 Dec 31. PMID 15485874
  3. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling. Sudo K, et al. Hum Mutat, 2007 Oct. PMID 17546647
  4. Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. Tsang CW, et al. Mol Cell Biol, 2008 Dec. PMID 18809578, Free PMC Article
  5. Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, et al. Mol Cell Proteomics, 2007 May. PMID 16854843

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Electron microscopy immunocytochemistry of the cerebellum revealed the accumulation of septin 11 at the neck of dendritic spines, at the bifurcation of dendritic branches, and at some GABAergic synapses.
    Title: Septin 11 is present in GABAergic synapses and plays a functional role in the cytoarchitecture of neurons and GABAergic synaptic connectivity.
  2. SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
    Title: SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
  3. Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption.
    Title: Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic specialization of symmetric synapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex ISO
Inferred from Sequence Orthology
more info
  
part_of septin complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
septin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107208.3 → NP_001100678.1  septin-11

    See identical proteins and their annotated locations for NP_001100678.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6AAG9
    Related
    ENSRNOP00000090314.1, ENSRNOT00000100885.2
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    15119760..15275222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091849.2 → XP_038947777.1  septin-11 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZNQ9, A0A8I6AAG9
    Related
    ENSRNOP00000078633.1, ENSRNOT00000111632.2
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  2. XM_039091850.2 → XP_038947778.1  septin-11 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AAG9
    Related
    ENSRNOP00000069146.2, ENSRNOT00000091577.3
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  3. XM_039091848.2 → XP_038947776.1  septin-11 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AAG9, A0A8L2QUR1
    Related
    ENSRNOP00000062626.2, ENSRNOT00000067222.4
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  4. XM_039091846.2 → XP_038947774.1  septin-11 isoform X2

    UniProtKB/Swiss-Prot
    B3DMA8, B3GNI4, B3GNI6
    UniProtKB/TrEMBL
    A0A8I6AAG9
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  5. XM_039091843.2 → XP_038947771.1  septin-11 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AAG9
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  6. XM_039091845.2 → XP_038947773.1  septin-11 isoform X2

    UniProtKB/Swiss-Prot
    B3DMA8, B3GNI4, B3GNI6
    UniProtKB/TrEMBL
    A0A8I6AAG9
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  7. XM_039091844.2 → XP_038947772.1  septin-11 isoform X2

    UniProtKB/Swiss-Prot
    B3DMA8, B3GNI4, B3GNI6
    UniProtKB/TrEMBL
    A0A8I6AAG9
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  8. XM_039091842.2 → XP_038947770.1  septin-11 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AAG9
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

  9. XM_039091847.2 → XP_038947775.1  septin-11 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JUL7, A0A8I6AAG9, A6KK55
    Related
    ENSRNOP00000100818.1, ENSRNOT00000168068.1
    Conserved Domains (1) summary
    cd01850
    Location:38 → 306
    CDC_Septin; CDC/Septin GTPase family

RNA

  1. XR_005492931.2 RNA Sequence

  2. XR_005492933.2 RNA Sequence

  3. XR_005492932.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B3GNI6.1 GenPept UniProtKB/Swiss-Prot:B3GNI6

Gene LinkOut

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