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Stap1 signal transducing adaptor family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305269, updated on 14-Nov-2024

Summary

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Official Symbol
Stap1provided by RGD
Official Full Name
signal transducing adaptor family member 1provided by RGD
Primary source
RGD:1311584
See related
EnsemblRapid:ENSRNOG00000002014 AllianceGenome:RGD:1311584
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Stap-1; RGD1311584
Summary
Predicted to enable phosphotyrosine residue binding activity; protein tyrosine kinase activator activity; and signaling receptor binding activity. Predicted to be involved in several processes, including negative regulation of macrophage migration; negative regulation of ruffle assembly; and regulation of signal transduction. Predicted to act upstream of or within response to bacterium. Predicted to be located in several cellular components, including centriolar satellite; mitochondrion; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human STAP1 (signal transducing adaptor family member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 229.8), Thymus (RPKM 111.5) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Stap1 in Genome Data Viewer
Location:
14p21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (22301278..22336218, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (21950466..21981395, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (23575400..23604984, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 11C Neighboring gene uncharacterized LOC103692776 Neighboring gene gonadotropin releasing hormone receptor Neighboring gene ubiquitin-like modifier activating enzyme 6 Neighboring gene centromere protein C Neighboring gene actin, alpha 1, skeletal muscle, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loops govern SH2 domain specificity by controlling access to binding pockets. Kaneko T, et al. Sci Signal, 2010 May 4. PMID 20442417, Free PMC Article
  2. Induction of STAP-1 promotes neurotoxic activation of microglia. Stoecker K, et al. Biochem Biophys Res Commun, 2009 Jan 30. PMID 19100238
  3. Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. Ohya K, et al. Proc Natl Acad Sci U S A, 1999 Oct 12. PMID 10518561, Free PMC Article
  4. S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. Djouder N, et al. Mol Cell, 2007 Oct 12. PMID 17936702
  5. Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. Masuhara M, et al. Biochem Biophys Res Commun, 2000 Feb 24. PMID 10679268

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109040

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables macrophage colony-stimulating factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of macrophage colony-stimulating factor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microglial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of microglial cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of microglial cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phagocytosis, engulfment ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal-transducing adaptor protein 1
Names
stem cell adaptor protein STAP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025115.1 → NP_001020286.1  signal-transducing adaptor protein 1

    See identical proteins and their annotated locations for NP_001020286.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091249
    UniProtKB/TrEMBL
    A0A8I6ACF3, Q5BK11
    Related
    ENSRNOP00000002760.5, ENSRNOT00000002760.7
    Conserved Domains (2) summary
    cd10403
    Location:178 → 271
    SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)
    cl17171
    Location:15 → 139
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    22301278..22336218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017599182.3 → XP_017454671.1  signal-transducing adaptor protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZSB1, A6JCR9
    Related
    ENSRNOP00000081110.1, ENSRNOT00000096289.2

  2. XM_006250812.4 → XP_006250874.1  signal-transducing adaptor protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ACF3
    Related
    ENSRNOP00000110149.1, ENSRNOT00000126926.1
    Conserved Domains (2) summary
    cd10403
    Location:178 → 271
    SH2_STAP1; Src homology 2 domain found in Signal-transducing adaptor protein 1 (STAP1)
    cl17171
    Location:15 → 139
    PH-like; Pleckstrin homology-like domain

  3. XM_017599181.2 → XP_017454670.1  signal-transducing adaptor protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ACF3
Nucleotide Protein Strain
Heading Accession and Version

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