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Exoc1 exocyst complex component 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305287, updated on 2-Nov-2024

Summary

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Official Symbol
Exoc1provided by RGD
Official Full Name
exocyst complex component 1provided by RGD
Primary source
RGD:1304939
See related
EnsemblRapid:ENSRNOG00000002144 AllianceGenome:RGD:1304939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sec3l1
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to act upstream of or within embryo implantation. Predicted to be located in cytoplasm. Predicted to be part of exocyst. Predicted to be active in plasma membrane. Orthologous to human EXOC1 (exocyst complex component 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 154.2), Spleen (RPKM 136.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Exoc1 in Genome Data Viewer
Location:
14p11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31965782..32014156, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31611536..31659920, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (34132210..34192296, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene ribosomal protein L23a, pseudogene 19 Neighboring gene centrosomal protein 135 Neighboring gene exocyst complex component 1 like Neighboring gene uncharacterized LOC102556008

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within embryo implantation ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of exocyst IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exocyst complex component 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024770.2 → NP_001019941.2  exocyst complex component 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2JYT4
    Related
    ENSRNOP00000070781.2, ENSRNOT00000091230.3

  2. NM_001401331.1 → NP_001388260.1  exocyst complex component 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  3. NM_001401332.1 → NP_001388261.1  exocyst complex component 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  4. NM_001401333.1 → NP_001388262.1  exocyst complex component 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2K2V5
    Related
    ENSRNOP00000072393.2, ENSRNOT00000090470.3

  5. NM_001401334.1 → NP_001388263.1  exocyst complex component 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I5ZLJ5

  6. NM_001401335.1 → NP_001388264.1  exocyst complex component 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000087358.2, ENSRNOT00000116085.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    31965782..32014156 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273076.1 → XP_063129146.1  exocyst complex component 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A8D1

  2. XM_039091880.2 → XP_038947808.1  exocyst complex component 1 isoform X2

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:184 → 889
    Sec3_C; Exocyst complex component Sec3

  3. XM_039091877.2 → XP_038947805.1  exocyst complex component 1 isoform X1

    Related
    ENSRNOP00000078584.2, ENSRNOT00000106895.2
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191 → 896
    Sec3_C; Exocyst complex component Sec3

  4. XM_039091878.2 → XP_038947806.1  exocyst complex component 1 isoform X1

    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    pfam09763
    Location:191 → 896
    Sec3_C; Exocyst complex component Sec3

  5. XM_063273075.1 → XP_063129145.1  exocyst complex component 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K2V5

  6. XM_063273077.1 → XP_063129147.1  exocyst complex component 1 isoform X5

  7. XM_063273078.1 → XP_063129148.1  exocyst complex component 1 isoform X6

  8. XM_063273080.1 → XP_063129150.1  exocyst complex component 1 isoform X9

  9. XM_063273079.1 → XP_063129149.1  exocyst complex component 1 isoform X8

  10. XM_039091886.2 → XP_038947814.1  exocyst complex component 1 isoform X7

    UniProtKB/TrEMBL
    Q4V8H2
    Conserved Domains (2) summary
    cd14683
    Location:3 → 120
    PH-EXOC1; PH-like domain of Exocyst complex component 1
    cl19950
    Location:191 → 683
    Sec3_C; Exocyst complex component Sec3

  11. XM_063273081.1 → XP_063129151.1  exocyst complex component 1 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JYT4
Nucleotide Protein Strain
Heading Accession and Version

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