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Cep135 centrosomal protein 135 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305288, updated on 2-Nov-2024

Summary

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Official Symbol
Cep135provided by RGD
Official Full Name
centrosomal protein 135provided by RGD
Primary source
RGD:1310726
See related
EnsemblRapid:ENSRNOG00000002153 AllianceGenome:RGD:1310726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310726
Summary
Predicted to enable microtubule binding activity and protein homodimerization activity. Predicted to be involved in centrosome cycle; positive regulation of establishment of protein localization; and positive regulation of non-motile cilium assembly. Predicted to be located in cytoplasm. Predicted to be active in centriole and centrosome. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8. Orthologous to human CEP135 (centrosomal protein 135). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 52.5), Spleen (RPKM 39.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cep135 in Genome Data Viewer
Location:
14p11
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (31884774..31950050, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (31530538..31595812, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (34052168..34115763, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096736 Neighboring gene capping protein inhibiting regulator of actin dynamics Neighboring gene ribosomal protein L23a, pseudogene 19 Neighboring gene exocyst complex component 1 Neighboring gene exocyst complex component 1 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization. Kim K, et al. Exp Cell Res, 2008 Dec 10. PMID 18851962
  2. The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation. Hori A, et al. Biochem Biophys Res Commun, 2015 Dec 4-11. PMID 26545777, Free PMC Article
  3. Plk4-induced centriole biogenesis in human cells. Kleylein-Sohn J, et al. Dev Cell, 2007 Aug. PMID 17681131
  4. CEP295 interacts with microtubules and is required for centriole elongation. Chang CW, et al. J Cell Sci, 2016 Jul 1. PMID 27185865, Free PMC Article
  5. ARFGAP1 promotes AP-2-dependent endocytosis. Bai M, et al. Nat Cell Biol, 2011 May. PMID 21499258, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centriole replication ISO
Inferred from Sequence Orthology
more info
  
involved_in centriole-centriole cohesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
centrosomal protein of 135 kDa
Names
centrosomal protein 135kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398887.1 → NP_001385816.1  centrosomal protein of 135 kDa

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    D3ZI35
    Related
    ENSRNOP00000096498.2, ENSRNOT00000108575.2
    Conserved Domains (2) summary
    COG1196
    Location:202 → 994
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22292
    Location:81 → 142
    cc_Cep135_MBD; coiled-coil microtubule binding domain of centrosomal protein of 135 kDa (Cep135) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    31884774..31950050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250874.4 → XP_006250936.1  centrosomal protein of 135 kDa isoform X1

    See identical proteins and their annotated locations for XP_006250936.1

    UniProtKB/TrEMBL
    A0A8I6AQK7, D3ZI35
    Conserved Domains (2) summary
    COG1196
    Location:202 → 994
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22292
    Location:81 → 142
    cc_Cep135_MBD; coiled-coil microtubule binding domain of centrosomal protein of 135 kDa (Cep135) and similar proteins

  2. XM_223341.10 → XP_223341.6  centrosomal protein of 135 kDa isoform X1

    See identical proteins and their annotated locations for XP_223341.6

    UniProtKB/TrEMBL
    A0A8I6AQK7, D3ZI35
    Conserved Domains (2) summary
    COG1196
    Location:202 → 994
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22292
    Location:81 → 142
    cc_Cep135_MBD; coiled-coil microtubule binding domain of centrosomal protein of 135 kDa (Cep135) and similar proteins

  3. XM_039092701.2 → XP_038948629.1  centrosomal protein of 135 kDa isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:202 → 950
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22292
    Location:81 → 142
    cc_Cep135_MBD; coiled-coil microtubule binding domain of centrosomal protein of 135 kDa (Cep135) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

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