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Apbb2 amyloid beta precursor protein binding family B member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305338, updated on 10-Jul-2024

Summary

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Symbol
Apbb2provided by RGD
Full Name
amyloid beta precursor protein binding family B member 2provided by RGD
Primary source
RGD:1562438
See related
EnsemblRapid:ENSRNOG00000063717 AllianceGenome:RGD:1562438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562438
Summary
Predicted to enable amyloid-beta binding activity. Predicted to be involved in several processes, including maintenance of lens transparency; negative regulation of cell cycle phase transition; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within extracellular matrix organization; generation of neurons; and regulation of apoptotic process. Predicted to be located in Golgi apparatus; early endosome; and endoplasmic reticulum. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 267.6), Heart (RPKM 236.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Apbb2 in Genome Data Viewer
Location:
14p11
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (41849638..42232930)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (41557918..41878622)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43205047..43526968)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene LIM and calponin homology domains 1 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134481847 Neighboring gene U6 spliceosomal RNA Neighboring gene ubiquitin C-terminal hydrolase L1 Neighboring gene uncharacterized LOC134481846 Neighboring gene NOP2/Sun RNA methyltransferase family member 7 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians. Golanska E, et al. Exp Gerontol, 2013 Apr. PMID 23384821
  2. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Li Y, et al. Hum Mutat, 2005 Mar. PMID 15714520
  3. Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Hsu LJ, et al. Biochem Biophys Res Commun, 2005 Feb 11. PMID 15629131
  4. Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. Bruni P, et al. J Biol Chem, 2002 Sep 20. PMID 12089154
  5. Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. Guénette S, et al. EMBO J, 2006 Jan 25. PMID 16407979, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within extracellular matrix organization ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of lens transparency ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
amyloid beta precursor protein binding family B member 2
Names
amyloid beta (A4) precursor protein-binding, family B, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427465.1 → NP_001414394.1  amyloid beta precursor protein binding family B member 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I6A9I8
    Related
    ENSRNOP00000088203.1, ENSRNOT00000106751.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    41849638..42232930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273105.1 → XP_063129175.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6

  2. XM_063273114.1 → XP_063129184.1  amyloid beta precursor protein binding family B member 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZYC7

  3. XM_039092527.2 → XP_038948455.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6
    Conserved Domains (3) summary
    cd01271
    Location:583 → 709
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:417 → 554
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  4. XM_063273111.1 → XP_063129181.1  amyloid beta precursor protein binding family B member 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A9I8

  5. XM_039092530.2 → XP_038948458.1  amyloid beta precursor protein binding family B member 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZYC7
    Related
    ENSRNOP00000082727.2, ENSRNOT00000100119.2
    Conserved Domains (3) summary
    cd01271
    Location:562 → 688
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:396 → 533
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:293 → 321
    WW; WW domain

  6. XM_063273115.1 → XP_063129185.1  amyloid beta precursor protein binding family B member 2 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZYC7
    Related
    ENSRNOP00000084619.2, ENSRNOT00000115068.2

  7. XM_063273113.1 → XP_063129183.1  amyloid beta precursor protein binding family B member 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A9I8

  8. XM_039092531.2 → XP_038948459.1  amyloid beta precursor protein binding family B member 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZYC7
    Conserved Domains (3) summary
    cd01271
    Location:561 → 687
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395 → 532
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  9. XM_039092532.2 → XP_038948460.1  amyloid beta precursor protein binding family B member 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZYC7
    Conserved Domains (3) summary
    cd01271
    Location:560 → 686
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
    cd01272
    Location:395 → 532
    PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain
    pfam00397
    Location:292 → 320
    WW; WW domain

  10. XM_063273104.1 → XP_063129174.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6

  11. XM_063273103.1 → XP_063129173.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6

  12. XM_063273108.1 → XP_063129178.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6

  13. XM_063273107.1 → XP_063129177.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6

  14. XM_063273109.1 → XP_063129179.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6

  15. XM_063273112.1 → XP_063129182.1  amyloid beta precursor protein binding family B member 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A9I8

  16. XM_063273106.1 → XP_063129176.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6

  17. XM_063273102.1 → XP_063129172.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6

  18. XM_063273110.1 → XP_063129180.1  amyloid beta precursor protein binding family B member 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A9I8, A0A8I6G7S6

  19. XM_063273116.1 → XP_063129186.1  amyloid beta precursor protein binding family B member 2 isoform X9

  20. XM_063273117.1 → XP_063129187.1  amyloid beta precursor protein binding family B member 2 isoform X10

  21. XM_063273120.1 → XP_063129190.1  amyloid beta precursor protein binding family B member 2 isoform X12

  22. XM_063273119.1 → XP_063129189.1  amyloid beta precursor protein binding family B member 2 isoform X11

  23. XM_017599457.3 → XP_017454946.1  amyloid beta precursor protein binding family B member 2 isoform X14

    UniProtKB/TrEMBL
    F1LZU7
    Conserved Domains (1) summary
    cd01271
    Location:34 → 160
    PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

  24. XM_063273122.1 → XP_063129192.1  amyloid beta precursor protein binding family B member 2 isoform X14

  25. XM_063273121.1 → XP_063129191.1  amyloid beta precursor protein binding family B member 2 isoform X13

Nucleotide Protein Strain
Heading Accession and Version

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