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Rbm47 RNA binding motif protein 47 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305340, updated on 2-Nov-2024

Summary

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Official Symbol
Rbm47provided by RGD
Official Full Name
RNA binding motif protein 47provided by RGD
Primary source
RGD:1359713
See related
EnsemblRapid:ENSRNOG00000002408 AllianceGenome:RGD:1359713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1359713
Summary
Predicted to enable enzyme binding activity; enzyme-substrate adaptor activity; and mRNA 3'-UTR binding activity. Predicted to be involved in positive regulation of type I interferon-mediated signaling pathway and regulation of gene expression. Predicted to act upstream of or within cytidine to uridine editing and hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm. Predicted to be part of apolipoprotein B mRNA editing enzyme complex. Predicted to be active in nucleus. Orthologous to human RBM47 (RNA binding motif protein 47). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 262.2), Adrenal (RPKM 123.2) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbm47 in Genome Data Viewer
Location:
14p11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (42407226..42545304)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42053290..42191572)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43701944..43839803)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120096606 Neighboring gene ribosomal protein S23 like 1 Neighboring gene cholinergic receptor nicotinic alpha 9 subunit Neighboring gene HAUS augmin-like complex, subunit 8, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47. Fossat N, et al. EMBO Rep, 2014 Aug. PMID 24916387, Free PMC Article
  2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC94215

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cytidine to uridine editing ISO
Inferred from Sequence Orthology
more info
  
involved_in cytidine to uridine editing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of apolipoprotein B mRNA editing enzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein 47
Names
hypothetical RNA binding protein RGD1359713

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005882.1 → NP_001005882.1  RNA-binding protein 47

    See identical proteins and their annotated locations for NP_001005882.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081995
    UniProtKB/Swiss-Prot
    Q66H68
    UniProtKB/TrEMBL
    A0A8I6AD79, A6JDC5
    Related
    ENSRNOP00000003327.5, ENSRNOT00000003327.8
    Conserved Domains (1) summary
    TIGR01648
    Location:11 → 590
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    42407226..42545304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250951.4 → XP_006251013.1  RNA-binding protein 47 isoform X1

    See identical proteins and their annotated locations for XP_006251013.1

    UniProtKB/Swiss-Prot
    Q66H68
    UniProtKB/TrEMBL
    A0A8I6AD79, A6JDC5
    Conserved Domains (1) summary
    TIGR01648
    Location:11 → 590
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  2. XM_063273127.1 → XP_063129197.1  RNA-binding protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q66H68
    UniProtKB/TrEMBL
    A6JDC5

  3. XM_063273128.1 → XP_063129198.1  RNA-binding protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q66H68
    UniProtKB/TrEMBL
    A6JDC5

  4. XM_063273126.1 → XP_063129196.1  RNA-binding protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q66H68
    UniProtKB/TrEMBL
    A6JDC5

  5. XM_063273129.1 → XP_063129199.1  RNA-binding protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q66H68
    UniProtKB/TrEMBL
    A6JDC5

  6. XM_063273130.1 → XP_063129200.1  RNA-binding protein 47 isoform X1

    UniProtKB/Swiss-Prot
    Q66H68
    UniProtKB/TrEMBL
    A6JDC5

  7. XM_006250949.5 → XP_006251011.1  RNA-binding protein 47 isoform X1

    See identical proteins and their annotated locations for XP_006251011.1

    UniProtKB/Swiss-Prot
    Q66H68
    UniProtKB/TrEMBL
    A0A8I6AD79, A6JDC5
    Conserved Domains (1) summary
    TIGR01648
    Location:11 → 590
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66H68.1 GenPept UniProtKB/Swiss-Prot:Q66H68

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