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Arap2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305367, updated on 18-Sep-2024

Summary

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Official Symbol
Arap2provided by RGD
Official Full Name
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2provided by RGD
Primary source
RGD:1306452
See related
EnsemblRapid:ENSRNOG00000056826 AllianceGenome:RGD:1306452
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Centd1
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in positive regulation of GTPase activity and signal transduction. Predicted to be located in cytoplasm. Orthologous to human ARAP2 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 199.5), Lung (RPKM 180.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arap2 in Genome Data Viewer
Location:
14q11
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (50921323..51120972)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (46717657..46917326)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (48726033..48922809)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene transformer 2 beta, pseudogene 1 Neighboring gene death domain containing 1 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA17 Neighboring gene actin related protein 2, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Krugmann S, et al. Mol Cell, 2002 Jan. PMID 11804589
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Names
centaurin, delta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107216.1 → NP_001100686.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

    See identical proteins and their annotated locations for NP_001100686.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473963
    UniProtKB/TrEMBL
    A0A0G2K7I9, A6IJD8
    Conserved Domains (7) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:1110 → 1289
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:480 → 571
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:581 → 671
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd17227
    Location:1298 → 1395
    RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
    cd08856
    Location:676 → 796
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
    cl17171
    Location:1401 → 1512
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    50921323..51120972
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091929.2 → XP_038947857.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1

    Conserved Domains (7) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:1110 → 1289
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:480 → 571
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:581 → 671
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd17227
    Location:1335 → 1432
    RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
    cd08856
    Location:676 → 796
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
    cl17171
    Location:1438 → 1549
    PH-like; Pleckstrin homology-like domain

  2. XM_039091938.2 → XP_038947866.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X7

    Conserved Domains (4) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd13253
    Location:480 → 571
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:581 → 671
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd08856
    Location:676 → 796
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2

  3. XM_039091932.2 → XP_038947860.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X4

    Conserved Domains (7) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:1110 → 1289
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:480 → 571
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:581 → 671
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd17227
    Location:1335 → 1432
    RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
    cd08856
    Location:676 → 796
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
    cl17171
    Location:888 → 998
    PH-like; Pleckstrin homology-like domain

  4. XM_039091937.2 → XP_038947865.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X6

    Conserved Domains (5) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd13253
    Location:480 → 571
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:581 → 671
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd08856
    Location:676 → 796
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
    cl17171
    Location:888 → 996
    PH-like; Pleckstrin homology-like domain

  5. XM_039091927.2 → XP_038947855.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X1

    Related
    ENSRNOP00000103220.1, ENSRNOT00000164131.1
    Conserved Domains (7) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:1110 → 1289
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:480 → 571
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:581 → 671
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd17227
    Location:1335 → 1432
    RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
    cd08856
    Location:676 → 796
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
    cl17171
    Location:1438 → 1549
    PH-like; Pleckstrin homology-like domain

  6. XM_039091930.2 → XP_038947858.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A096MK16
    Related
    ENSRNOP00000070433.2, ENSRNOT00000082599.3
    Conserved Domains (7) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:1110 → 1289
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:480 → 571
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:581 → 671
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd17227
    Location:1321 → 1418
    RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
    cd08856
    Location:676 → 796
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
    cl17171
    Location:1424 → 1535
    PH-like; Pleckstrin homology-like domain

  7. XM_039091931.2 → XP_038947859.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K7I9, A6IJD8
    Related
    ENSRNOP00000074225.2, ENSRNOT00000086646.3
    Conserved Domains (7) summary
    cd09490
    Location:6 → 68
    SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
    cd04385
    Location:1110 → 1289
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13253
    Location:480 → 571
    PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
    cd13254
    Location:581 → 671
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd17227
    Location:1298 → 1395
    RA_ARAP2; Ras-associating (RA) domain found in Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)
    cd08856
    Location:676 → 796
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
    cl17171
    Location:1401 → 1512
    PH-like; Pleckstrin homology-like domain

  8. XM_039091936.2 → XP_038947864.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 isoform X5

    Conserved Domains (5) summary
    cd04385
    Location:604 → 783
    RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
    cd13254
    Location:75 → 165
    PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
    cd08856
    Location:170 → 290
    ArfGap_ARAP2; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 2
    cl17171
    Location:932 → 1043
    PH-like; Pleckstrin homology-like domain
    cl28922
    Location:829 → 926
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RNA

  1. XR_005492952.2 RNA Sequence

  2. XR_005492953.2 RNA Sequence

  3. XR_010057366.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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