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Fbxl5 F-box and leucine-rich repeat protein 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305424, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxl5provided by RGD
Official Full Name
F-box and leucine-rich repeat protein 5provided by RGD
Primary source
RGD:1306887
See related
EnsemblRapid:ENSRNOG00000005261 AllianceGenome:RGD:1306887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable iron ion binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; intracellular iron ion homeostasis; and protein ubiquitination. Predicted to act upstream of or within multicellular organismal-level iron ion homeostasis and positive regulation of protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL5 (F-box and leucine rich repeat protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 368.6), Brain (RPKM 323.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fbxl5 in Genome Data Viewer
Location:
14q21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (71517452..71559850)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (67305109..67347383)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (71852649..71891143)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene uncharacterized LOC108352765 Neighboring gene cytochrome c, somatic pseudogene Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene C1q and TNF related 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FBXL5 interacts with p150Glued and regulates its ubiquitination. Zhang N, et al. Biochem Biophys Res Commun, 2007 Jul 20. PMID 17532294
  2. Control of iron homeostasis by an iron-regulated ubiquitin ligase. Vashisht AA, et al. Science, 2009 Oct 30. PMID 19762596, Free PMC Article
  3. An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Salahudeen AA, et al. Science, 2009 Oct 30. PMID 19762597, Free PMC Article
  4. The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Moroishi T, et al. Cell Metab, 2011 Sep 7. PMID 21907140
  5. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, et al. Biochim Biophys Acta, 2015 May. PMID 25661197

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/LRR-repeat protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401432.1 → NP_001388361.1  F-box/LRR-repeat protein 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2JTC9
    Related
    ENSRNOP00000110832.1, ENSRNOT00000172538.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    71517452..71559850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091944.2 → XP_038947872.1  F-box/LRR-repeat protein 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZSP0, A0A8I6AK75
    Related
    ENSRNOP00000101249.1, ENSRNOT00000126192.1
    Conserved Domains (4) summary
    cd09293
    Location:324 → 388
    AMN1; Antagonist of mitotic exit network protein 1
    cd12109
    Location:13 → 144
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    sd00034
    Location:342 → 368
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:189 → 233
    F-box-like

  2. XM_063273139.1 → XP_063129209.1  F-box/LRR-repeat protein 5 isoform X2

    Related
    ENSRNOP00000093757.2, ENSRNOT00000101227.2

  3. XM_063273140.1 → XP_063129210.1  F-box/LRR-repeat protein 5 isoform X5

  4. XM_039091946.2 → XP_038947874.1  F-box/LRR-repeat protein 5 isoform X4

    Conserved Domains (2) summary
    cd12109
    Location:7 → 160
    Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
    pfam12937
    Location:205 → 249
    F-box-like

  5. XM_017599194.3 → XP_017454683.1  F-box/LRR-repeat protein 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZSP0

  6. XM_017599195.3 → XP_017454684.1  F-box/LRR-repeat protein 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZSP0

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107222.1: Suppressed sequence

    Description
    NM_001107222.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

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