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Zbtb49 zinc finger and BTB domain containing 49 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305428, updated on 2-Nov-2024

Summary

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Official Symbol
Zbtb49provided by RGD
Official Full Name
zinc finger and BTB domain containing 49provided by RGD
Primary source
RGD:1306733
See related
EnsemblRapid:ENSRNOG00000005633 AllianceGenome:RGD:1306733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfp509; Znf509
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Predicted to be involved in several processes, including negative regulation of cell population proliferation; regulation of cell cycle; and regulation of gene expression. Predicted to be located in cytosol; microtubule cytoskeleton; and nucleus. Predicted to be active in nucleoplasm. Orthologous to human ZBTB49 (zinc finger and BTB domain containing 49). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 27.8), Adrenal (RPKM 27.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zbtb49 in Genome Data Viewer
Location:
14q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (76802988..76835573)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (72590692..72612404)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (77322014..77343736)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481772 Neighboring gene Ly1 antibody reactive Neighboring gene uncharacterized LOC120096634 Neighboring gene neuronal vesicle trafficking associated 1 Neighboring gene syntaxin 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress. Jeon BN, et al. Nucleic Acids Res, 2014 Oct. PMID 25245946, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 49
Names
zinc finger protein 509

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394682.2 → NP_001381611.1  zinc finger and BTB domain-containing protein 49 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2JT85
    Related
    ENSRNOP00000109353.1, ENSRNOT00000126176.1
    Conserved Domains (5) summary
    PHA03247
    Location:121 → 300
    PHA03247; large tegument protein UL36; Provisional
    COG5048
    Location:400 → 578
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:502 → 522
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18233
    Location:7 → 118
    BTB_POZ_ZBTB49; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49)
    pfam00096
    Location:388 → 410
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001401386.1 → NP_001388315.1  zinc finger and BTB domain-containing protein 49 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000042665.3, ENSRNOT00000041639.4

  3. NM_001401387.1 → NP_001388316.1  zinc finger and BTB domain-containing protein 49 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000068611.2, ENSRNOT00000088600.3

RNA

  1. NR_174703.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  2. NR_174704.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    76802988..76835573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273141.1 → XP_063129211.1  zinc finger and BTB domain-containing protein 49 isoform X1

  2. XM_063273142.1 → XP_063129212.1  zinc finger and BTB domain-containing protein 49 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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