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Jakmip1 janus kinase and microtubule interacting protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305434, updated on 2-Nov-2024

Summary

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Official Symbol
Jakmip1provided by RGD
Official Full Name
janus kinase and microtubule interacting protein 1provided by RGD
Primary source
RGD:1562401
See related
EnsemblRapid:ENSRNOG00000004998 AllianceGenome:RGD:1562401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Marlin1; Marlin-1
Summary
Predicted to enable GABA receptor binding activity; RNA binding activity; and kinesin binding activity. Predicted to be involved in cognition. Located in microtubule cytoskeleton. Orthologous to human JAKMIP1 (janus kinase and microtubule interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 119.2), Thymus (RPKM 89.5) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Jakmip1 in Genome Data Viewer
Location:
14q21
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (77871034..77991566, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (73646299..73766830, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (78403448..78523108, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene EvC ciliary complex subunit 1 Neighboring gene collapsin response mediator protein 1 Neighboring gene glyoxalase 1, pseudogene 1 Neighboring gene similar to human chromosome 4 open reading frame 50 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134481775

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons. Vidal RL, et al. Mol Cell Neurosci, 2012 Aug. PMID 22828129
  2. Cellular and subcellular localization of Marlin-1 in the brain. Vidal RL, et al. BMC Neurosci, 2009 Apr 22. PMID 19386132, Free PMC Article
  3. Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors. Vidal RL, et al. J Cell Biochem, 2008 Feb 15. PMID 17668444
  4. Marlin-1, a novel RNA-binding protein associates with GABA receptors. Couve A, et al. J Biol Chem, 2004 Apr 2. PMID 14718537
  5. Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport. Vidal RL, et al. Mol Cell Neurosci, 2007 Jul. PMID 17532644

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Marlin-1 is enriched in restricted areas of the brain including olfactory bulb, cerebral cortex, hippocampus and cerebellum; it is abundant in dendrites and axons of hippocampal neurons, associated with microtubules at the ultrastructural level.
    Title: Cellular and subcellular localization of Marlin-1 in the brain.
  2. Our findings demonstrate that Marlin-1 associates with a microtubule fraction and with GABA(B) receptors in testis suggesting that the set of protein interactions of Marlin-1 are conserved in different tissues.
    Title: Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors.
  3. Marlin-1 functions to regulate the cellular levels of GABA(B) R2 subunits, which may have significant effects on the production of functional GABA(B) receptor heterodimers.
    Title: Marlin-1, a novel RNA-binding protein associates with GABA receptors.
  4. RNA interference of Marlin-1 in vivo results in abnormal migration and abnormal morphology of newborn pyramidal neurons during the formation of the cortex.
    Title: RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC125191, MGC125215

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GABA receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GABA receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables GABA receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cognition IEA
Inferred from Electronic Annotation
more info
  
involved_in cognition ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
janus kinase and microtubule-interacting protein 1
Names
multiple alpha helices and RNA-linker protein 1
multiple coiled-coil GABABR1-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033894.1 → NP_001029066.1  janus kinase and microtubule-interacting protein 1 isoform 5

    See identical proteins and their annotated locations for NP_001029066.1

    Status: VALIDATED

    Source sequence(s)
    BC104677
    UniProtKB/Swiss-Prot
    Q3SWS9
    Conserved Domains (2) summary
    TIGR02169
    Location:6 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:416 → 604
    JAKMIP_CC3; JAKMIP CC3 domain

  2. NM_001401057.1 → NP_001387986.1  janus kinase and microtubule-interacting protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000006771.6, ENSRNOT00000006771.6

  3. NM_001401058.1 → NP_001387987.1  janus kinase and microtubule-interacting protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8L2Q2V8

  4. NM_001401059.1 → NP_001387988.1  janus kinase and microtubule-interacting protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  5. NM_001401060.1 → NP_001387989.1  janus kinase and microtubule-interacting protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    Related
    ENSRNOP00000103569.1, ENSRNOT00000125060.1

  6. NM_001401062.1 → NP_001387991.1  janus kinase and microtubule-interacting protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q3SWS9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    77871034..77991566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063273143.1 → XP_063129213.1  janus kinase and microtubule-interacting protein 1 isoform X5

  2. XM_017599204.3 → XP_017454693.1  janus kinase and microtubule-interacting protein 1 isoform X4

    UniProtKB/TrEMBL
    A6IJW6

  3. XM_017599201.3 → XP_017454690.1  janus kinase and microtubule-interacting protein 1 isoform X3

    UniProtKB/TrEMBL
    A6IJW6
    Related
    ENSRNOP00000105142.1, ENSRNOT00000150746.1

  4. XM_039091951.2 → XP_038947879.1  janus kinase and microtubule-interacting protein 1 isoform X2

    UniProtKB/TrEMBL
    A6IJW6
    Conserved Domains (2) summary
    TIGR02169
    Location:6 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:416 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  5. XM_017599199.3 → XP_017454688.1  janus kinase and microtubule-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6IJW6
    Conserved Domains (2) summary
    TIGR02169
    Location:6 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:416 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  6. XM_039091949.2 → XP_038947877.1  janus kinase and microtubule-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6IJW6
    Conserved Domains (2) summary
    TIGR02169
    Location:6 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:416 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  7. XM_039091948.2 → XP_038947876.1  janus kinase and microtubule-interacting protein 1 isoform X1

    UniProtKB/TrEMBL
    A6IJW6
    Conserved Domains (2) summary
    TIGR02169
    Location:6 → 363
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam16034
    Location:416 → 612
    JAKMIP_CC3; JAKMIP CC3 domain

  8. XM_063273146.1 → XP_063129216.1  janus kinase and microtubule-interacting protein 1 isoform X8

    Related
    ENSRNOP00000084871.1, ENSRNOT00000106540.2

  9. XM_039091952.2 → XP_038947880.1  janus kinase and microtubule-interacting protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZYV3
    Conserved Domains (2) summary
    TIGR02168
    Location:357 → 634
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16034
    Location:208 → 404
    JAKMIP_CC3; JAKMIP CC3 domain

  10. XM_039091953.2 → XP_038947881.1  janus kinase and microtubule-interacting protein 1 isoform X10

    Conserved Domains (2) summary
    TIGR02168
    Location:182 → 459
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam16034
    Location:33 → 229
    JAKMIP_CC3; JAKMIP CC3 domain

  11. XM_063273144.1 → XP_063129214.1  janus kinase and microtubule-interacting protein 1 isoform X6

    Related
    ENSRNOP00000107455.1, ENSRNOT00000172701.1

  12. XM_063273147.1 → XP_063129217.1  janus kinase and microtubule-interacting protein 1 isoform X9

    UniProtKB/Swiss-Prot
    Q3SWS9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SWS9.1 GenPept UniProtKB/Swiss-Prot:Q3SWS9

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