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Sorcs2 sortilin-related VPS10 domain containing receptor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305438, updated on 28-Oct-2024

Summary

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Official Symbol
Sorcs2provided by RGD
Official Full Name
sortilin-related VPS10 domain containing receptor 2provided by RGD
Primary source
RGD:1310621
See related
EnsemblRapid:ENSRNOG00000007033 AllianceGenome:RGD:1310621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in intracellular protein transport and long-term synaptic depression. Predicted to be located in several cellular components, including cytosol; endosome membrane; and postsynaptic density. Predicted to be active in membrane. Orthologous to human SORCS2 (sortilin related VPS10 domain containing receptor 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Lung (RPKM 88.5), Brain (RPKM 65.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sorcs2 in Genome Data Viewer
Location:
14q21
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (78592290..78960582)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (74371089..74735943)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (79538911..79912333)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transcriptional adaptor 2B Neighboring gene GrpE-like 1, mitochondrial Neighboring gene uncharacterized LOC134481854 Neighboring gene uncharacterized LOC134481853 Neighboring gene uncharacterized LOC134481778 Neighboring gene prosaposin-like 1 Neighboring gene actin filament associated protein 1 Neighboring gene uncharacterized LOC134481856 Neighboring gene uncharacterized LOC134481855

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. SorCS2 is required for BDNF-dependent plasticity in the hippocampus. Glerup S, et al. Mol Psychiatry, 2016 Dec. PMID 27457814
  2. SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Malik AR, et al. Cell Rep, 2019 Mar 5. PMID 30840898, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
VPS10 domain-containing receptor SorCS2
Names
VPS10 domain receptor protein SORCS 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107225.2 → NP_001100695.2  VPS10 domain-containing receptor SorCS2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A6IJY5
    Related
    ENSRNOP00000009960.8, ENSRNOT00000009960.9
    Conserved Domains (3) summary
    smart00602
    Location:170 → 776
    VPS10; VPS10 domain
    pfam00801
    Location:798 → 863
    PKD; PKD domain
    pfam15901
    Location:613 → 776
    Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    78592290..78960582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091958.2 → XP_038947886.1  VPS10 domain-containing receptor SorCS2 isoform X4

    Conserved Domains (1) summary
    smart00602
    Location:170 → 776
    VPS10; VPS10 domain

  2. XM_039091954.2 → XP_038947882.1  VPS10 domain-containing receptor SorCS2 isoform X1

    UniProtKB/TrEMBL
    A6IJY5, D3ZW09
    Conserved Domains (2) summary
    smart00602
    Location:170 → 776
    VPS10; VPS10 domain
    pfam00801
    Location:798 → 863
    PKD; PKD domain

  3. XM_039091957.2 → XP_038947885.1  VPS10 domain-containing receptor SorCS2 isoform X3

    UniProtKB/TrEMBL
    A6IJY5
    Conserved Domains (2) summary
    smart00602
    Location:1 → 604
    VPS10; VPS10 domain
    pfam00801
    Location:626 → 691
    PKD; PKD domain

  4. XM_039091956.2 → XP_038947884.1  VPS10 domain-containing receptor SorCS2 isoform X2

    UniProtKB/TrEMBL
    A6IJY5
    Conserved Domains (2) summary
    smart00602
    Location:70 → 676
    VPS10; VPS10 domain
    pfam00801
    Location:698 → 763
    PKD; PKD domain
Nucleotide Protein Strain
Heading Accession and Version

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